Sensibilisierung auf p-Phenylendiamin. Einfluss von Metabolisierung und individuellen Risikofaktoren

Titelvariante(n): Sensitisation to p-Phenylenediamine. Effects of metabolism and individual susceptibility
Autor(en): Brans, Richard 
Skazik, C.
Merk, Hans F.
Blömeke, Brunhilde
Affiliationen: Klinik für Dermatologie und Allergologie, Universitätsklinikum der RWTH Aachen, Pauwelsstrasse 30, 52074, Aachen. rbrans@ukaachen.de
Erscheinungsdatum: 2009
Journal: Der Hautarzt : Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete
Volumen: 60
Ausgabe: 1
Startseite: 26
Seitenende: 31
Zusammenfassung: 
Due to its constant exposure to small molecular weight compounds, the skin is a major target for allergic reactions. Para-phenylenediamine (PPD) is a common and strong contact allergen. Recent studies have revealed new aspects of steps involved in sensitization and allergic contact dermatitis to PPD, giving insight into the cutaneous metabolism of small molecular compounds and its effect on activation and deactivation of immunogenic substances. Molecular epidemiological studies have suggested that polymorphisms in genes encoding cytokines (e.g. TNF-alpha) or metabolizing enzymes (e.g. N-acetyltransferase) may have influence on these mechanisms and the individual susceptibility for sensitization.
DOI: 10.1007/s00105-008-1643-7

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