Integrin αE(CD103) Is Involved in Regulatory T-Cell Function in Allergic Contact Hypersensitivity
Autor(en): | Braun, Andrea Dewert, Nadin Brunnert, Fiona Schnabel, Viktor Hardenberg, Jan-Hendrik Richter, Beatrice Zachmann, Karolin Cording, Sascha Claßen, Anna Brans, Richard Hamann, Alf Huehn, Jochen Schön, Michael P. |
Erscheinungsdatum: | 2015 | Herausgeber: | Elsevier | Enthalten in: | The journal of investigative dermatology | Band: | 135 | Ausgabe: | 12 | Startseite: | 2982 | Seitenende: | 2991 | Zusammenfassung: | Murine contact hypersensitivity (CHS) is a dendritic cell (DC)-dependent T-cell-mediated inflammation with CD8+ T cells as effectors and CD4+ T cells as regulators (Treg cells) that models human allergic contact dermatitis. The integrin αE(CD103) is expressed by some T-cell and DC subsets and has been implicated in epithelial lymphocyte localization, but its role in immune regulation remains enigmatic. We have identified a function for CD103 in the development of cutaneous allergic immune responses. CHS responses, but not irritant contact dermatitis, were significantly augmented in CD103-deficient mice in hapten-challenged skin. Phenotype and function of skin DCs during sensitization were normal, whereas adoptive transfer experiments revealed that the elevated CHS response in CD103-deficient mice is transferred by primed T cells and is independent of resident cells in recipient mice. While T-cell counts were elevated in challenged skin of CD103-deficient mice, the FoxP3 expression level of CD4+CD25+ Treg cells was significantly reduced, indicating impaired functionality. Indeed, Treg cells from CD103-deficient mice were not able to suppress CHS reactions during the elicitation phase. Further, CD103 on FoxP3+ Treg cells was involved in Treg retention to inflamed skin. These findings indicate an unexpected dichotomous functional role for CD103 on Treg cells by modulating FoxP3 expression. |
Externe URL: | http://www.ncbi.nlm.nih.gov/pubmed/26203637 http://kxp.k10plus.de/DB=2.3/PPNSET?PPN=1964642337 |
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