Stratum corneum profiles of inflammatory mediators in patch test reactions to common contact allergens and sodium lauryl sulfate

Abstract

What's already known about this topic? Irritant and allergic contact dermatitis share a common inflammatory pathway. Recent studies have shown there is an allergen‐specific gene expression of inflammatory mediators in patch tested skin. What does this study add? The minimally invasive stratum corneum tape‐stripping technique can be used to detect a large number of inflammatory mediators. When applying standard patch test concentrations, methylchloroisothiazolinone/methylisothiazolinone was shown to be a more potent inducer of immune mediators than nickel, chromium and para ‐phenylenediamine. What is the translational message? Further investigations into interleukin‐16 in ACD might elucidate its function in the pathogenesis of ACD. The minimally invasive stratum corneum tape‐stripping technique can be used to detect a large number of inflammatory mediators. Respond to this article Linked Comment: Agner. Br J Dermatol 2017; 176:1434–1435 Plain language summary available online