Proton-Gradient-Driven Sensitivity Enhancement of Liposome-Encapsulated Supramolecular Chemosensors
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Nilam, Mohamed | |
dc.contributor.author | Karmacharya, Shreya | |
dc.contributor.author | Nau, Werner M. | |
dc.contributor.author | Hennig, Andreas | |
dc.date.accessioned | 2023-02-17T11:33:58Z | - |
dc.date.available | 2023-02-17T11:33:58Z | - |
dc.date.issued | 2022 | |
dc.identifier.issn | 1433-7851 | |
dc.identifier.uri | http://osnascholar.ub.uni-osnabrueck.de/handle/unios/65401 | - |
dc.description.abstract | An overarching challenge in the development of supramolecular sensor systems is to enhance their sensitivity, which commonly involves the synthesis of refined receptors with increased affinity to the analyte. We show that a dramatic sensitivity increase by 1-2 orders of magnitude can be achieved by encapsulating supramolecular chemosensors inside liposomes and exposing them to a pH gradient across the lipid bilayer membrane. This causes an imbalance of the influx and efflux rates of basic and acidic analytes leading to a significantly increased concentration of the analyte in the liposome interior. The utility of our liposome-enhanced sensors was demonstrated with various host-dye reporter pairs and sensing mechanisms, and we could easily increase the sensitivity towards multiple biologically relevant analytes, including the neurotransmitters serotonin and tryptamine. | |
dc.description.sponsorship | Deutsche Forschungsgemeinschaft [HE 5967/6-1, NA 686/15-1]; Financial support from the Deutsche Forschungsgemeinschaft (HE 5967/6-1 and NA 686/15-1) is gratefully acknowledged. Open Access funding enabled and organized by Projekt DEAL. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | |
dc.subject | ASSAYS | |
dc.subject | BETA-CYCLODEXTRIN | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | COMPLEXATION | |
dc.subject | DERIVATIVES | |
dc.subject | Host-Guest Systems | |
dc.subject | Liposomes | |
dc.subject | Macrocycles | |
dc.subject | PEPTIDES | |
dc.subject | pH Gradient | |
dc.subject | RECOGNITION | |
dc.subject | Sensors | |
dc.subject | Supramolecular Chemistry | |
dc.subject | SYSTEMS | |
dc.subject | TRANSPORT | |
dc.title | Proton-Gradient-Driven Sensitivity Enhancement of Liposome-Encapsulated Supramolecular Chemosensors | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/anie.202207950 | |
dc.identifier.isi | ISI:000823858600001 | |
dc.description.volume | 61 | |
dc.description.issue | 35 | |
dc.contributor.orcid | 0000-0002-7654-6232 | |
dc.contributor.orcid | 0000-0003-0444-5923 | |
dc.contributor.researcherid | E-6686-2011 | |
dc.contributor.researcherid | A-1438-2010 | |
dc.identifier.eissn | 1521-3773 | |
dc.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Angew. Chem.-Int. Edit. | |
dcterms.oaStatus | Green Published | |
local.import.remains | affiliations : University Osnabruck; University Osnabruck; Jacobs University | |
local.import.remains | earlyaccessdate : JUL 2022 | |
local.import.remains | web-of-science-index : Science Citation Index Expanded (SCI-EXPANDED) | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.orcid | 0000-0003-0444-5923 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | HeAn175 | - |
Seitenaufrufe
1
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 01.06.2024