Explicit Consideration of Temperature Improves Predictions of Toxicokinetic-Toxicodynamic Models for Flupyradifurone and Imidacloprid in Gammarus pulex
DC Element | Wert | Sprache |
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dc.contributor.author | Mangold-Doering, Annika | |
dc.contributor.author | Huang, Anna | |
dc.contributor.author | Van Nes, Egbert H. | |
dc.contributor.author | Focks, Andreas | |
dc.contributor.author | Van den Brink, Paul J. | |
dc.date.accessioned | 2023-02-17T11:35:00Z | - |
dc.date.available | 2023-02-17T11:35:00Z | - |
dc.date.issued | 2022 | |
dc.identifier.issn | 0013-936X | |
dc.identifier.uri | http://osnascholar.ub.uni-osnabrueck.de/handle/unios/65469 | - |
dc.description.abstract | In the face of global climate change, where temperature fluctuations and the frequency of extreme weather events are increasing, it is needed to evaluate the impact of temperature on the ecological risk assessment of chemicals. Current state-of-the-art mechanistic effect models, such as toxicokinetic-toxicodynamic (TK-TD) models, often do not explicitly consider temperature as a modulating factor. This study implemented the effect of temperature in a widely used modeling framework, the General Unified Threshold model for Survival (GUTS). We tested the model using data from toxicokinetic and toxicity experiments with Gammarus pulex exposed to the insecticides imidacloprid and flupyradifurone. The experiments revealed increased TK rates with increasing temperature and increased toxicity under chronic exposures. Using the widely used Arrhenius equation, we could include the temperature influence into the modeling. By further testing of different model approaches, differences in the temperature scaling of TK and TD model parameters could be identified, urging further investigations of the underlying mechanisms. Finally, our results show that predictions of TK-TD models improve if we include the toxicity modulating effect of temperature explicitly. | |
dc.description.sponsorship | European Union [201808320432]; China Scholarship Council; [813124]; The authors would like to thank Tjalling Jager for his technical support with BYOM software. Many tha n k s also to the two anonymous reviewers whose critical comments helped improve this article. This work is part of the Innovative Training Network ECORISK2050 and was supported by the European Union's Horizon 2020 research and innovation program under the Marie Sklodowska-Curie No 813124. A.H.was supported by the China Scholarship Council (No. 201808320432) . | |
dc.language.iso | en | |
dc.publisher | AMER CHEMICAL SOC | |
dc.relation.ispartof | ENVIRONMENTAL SCIENCE & TECHNOLOGY | |
dc.subject | CADMIUM | |
dc.subject | CHEMICALS | |
dc.subject | CHLORPYRIFOS | |
dc.subject | effect modeling | |
dc.subject | Engineering | |
dc.subject | Engineering, Environmental | |
dc.subject | Environmental Sciences | |
dc.subject | Environmental Sciences & Ecology | |
dc.subject | GUTS | |
dc.subject | INSECTICIDES | |
dc.subject | RECEPTOR | |
dc.subject | RESISTANCE | |
dc.subject | STRESSORS | |
dc.subject | TK-TD | |
dc.subject | TOXICITY | |
dc.subject | TOXICOLOGY | |
dc.title | Explicit Consideration of Temperature Improves Predictions of Toxicokinetic-Toxicodynamic Models for Flupyradifurone and Imidacloprid in Gammarus pulex | |
dc.type | journal article | |
dc.identifier.doi | 10.1021/acs.est.2c04085 | |
dc.identifier.isi | ISI:000880193800001 | |
dc.contributor.orcid | 0000-0002-7241-4347 | |
dc.contributor.orcid | 0000-0002-6701-308X | |
dc.identifier.eissn | 1520-5851 | |
dc.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | |
dcterms.isPartOf.abbreviation | Environ. Sci. Technol. | |
dcterms.oaStatus | Green Published | |
local.import.remains | affiliations : Wageningen University & Research; University Osnabruck; Wageningen University & Research | |
local.import.remains | earlyaccessdate : OCT 2022 | |
local.import.remains | web-of-science-index : Science Citation Index Expanded (SCI-EXPANDED) | |
crisitem.author.dept | FB 06 - Mathematik/Informatik/Physik | - |
crisitem.author.deptid | fb6 | - |
crisitem.author.orcid | 0000-0002-9031-0808 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | FoAn001 | - |
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geprüft am 06.06.2024