Rab GTPase Function in Endosome and Lysosome Biogenesis

Autor(en): Langemeyer, Lars
Froehlich, Florian 
Ungermann, Christian 
Stichwörter: BINDING-PROTEIN; Cell Biology; CUE DOMAIN; HOPS COMPLEX; MAMMALIAN CORVET; MEMBRANE-FUSION; NUCLEOTIDE EXCHANGE FACTOR; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; SIGNAL-TRANSDUCTION; UBIQUITIN BINDING; YEAST VACUOLE FUSION
Erscheinungsdatum: 2018
Herausgeber: ELSEVIER SCIENCE LONDON
Journal: TRENDS IN CELL BIOLOGY
Volumen: 28
Ausgabe: 11
Startseite: 957
Seitenende: 970
Zusammenfassung: 
Eukaryotic cells maintain a highly organized endolysosomal system. This system regulates the protein and lipid content of the plasma membrane, it participates in the intracellular quality control machinery and is needed for the efficient removal of damaged organelles. This complex network comprises an endosomal membrane system that feeds into the lysosomes, yet also allows recycling of membrane proteins, and probably lipids. Moreover, lysosomal degradation provides the cell with macromolecules for further growth. In this review, we focus primarily on the role of the small Rab GTPases Rab5 and Rab7 as organelle markers and interactors of multiple effectors on endosomes and lysosomes and highlight their role in membrane dynamics, particularly fusion along the endolysosomal pathway.
ISSN: 09628924
DOI: 10.1016/j.tcb.2018.06.007

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