Dioxidomolybdenum(VI) complexes of azo-hydrazones: Structural investigation, DNA binding and cytotoxicity studies

DC FieldValueLanguage
dc.contributor.authorDinda, Rupam
dc.contributor.authorMajumder, Sudarshana
dc.contributor.authorMohanty, Monalisa
dc.contributor.authorMohapatra, Deepika
dc.contributor.authorPatra, Sushree Aradhana
dc.contributor.authorParida, Rakesh
dc.contributor.authorGiri, Santanab
dc.contributor.authorReuter, Hans
dc.contributor.authorKausar, Chahat
dc.contributor.authorPatra, Samir Kumar
dc.date.accessioned2023-02-17T11:35:51Z-
dc.date.available2023-02-17T11:35:51Z-
dc.date.issued2022
dc.identifier.issn0277-5387
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/65531-
dc.description.abstractThe synthesis of three new dioxidomolybdenum(VI) complexes [MoO2L1-3(X)] (1-3) where X = EtOH for 1 and 3 and DMSO for 2 of aroylhydrazone ligands (H2L1-3) containing azobenzene moiety have been reported. H2L1-3 has been synthesized from the condensation of 5-(arylazo) salicylaldehyde derivatives with corresponding aroyl hydrazides. The azobenzene functionality was incorporated in the aroylhydrazone systems containing benzoyl, naphthyl and furyl moieties in order to explore their influence if any, on the biological properties of the corresponding molybdenum complexes. All the synthesized ligands and metal complexes were successfully characterized by elemental analysis, IR, UV-vis, NMR spectroscopy and HRMS. Redox properties of the complexes were studied by cyclic voltammetry. Molecular structures of 1-3 have been determined by X-ray crystallography. The electronic spectra of the complexes have been further analysed using time dependent density functional theory (TDDFT). DNA binding studies reveal that the complexes interact with calf-thymus DNA (CT-DNA) with binding constants in the range 10(4) M-1. The cytotoxicity activity of the complexes against A549 and HCT-15 cell lines has also been explored.
dc.description.sponsorshipCSIR [01 (3073) /21/EMR-11]; Acknowledgement RD thanks CSIR, [Grant No. 01 (3073) /21/EMR-11] for funding this research.
dc.language.isoen
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD
dc.relation.ispartofPOLYHEDRON
dc.subjectANTIBACTERIAL ACTIVITY
dc.subjectANTICANCER
dc.subjectAzobenzene
dc.subjectBASE LIGANDS SYNTHESIS
dc.subjectBIOLOGICAL EVALUATION
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectCrystallography
dc.subjectCytotoxicity
dc.subjectDERIVATIVES
dc.subjectDioxidomolybdenum(VI)
dc.subjectDIOXIDOVANADIUM(V) COMPLEXES
dc.subjectDNA binding
dc.subjectIRON CHELATORS
dc.subjectMETAL-COMPLEXES
dc.subjectPLATINUM(II) COMPLEXES
dc.subjectSCHIFF-BASES
dc.subjectX-ray crystal structure
dc.titleDioxidomolybdenum(VI) complexes of azo-hydrazones: Structural investigation, DNA binding and cytotoxicity studies
dc.typejournal article
dc.identifier.doi10.1016/j.poly.2022.116093
dc.identifier.isiISI:000857848800003
dc.description.volume227
dc.identifier.eissn1873-3719
dc.publisher.placeTHE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
dcterms.isPartOf.abbreviationPolyhedron
local.import.remainsaffiliations : National Institute of Technology (NIT System); National Institute of Technology Rourkela; Haldia Institute of Technology; University Osnabruck; National Institute of Technology (NIT System); National Institute of Technology Rourkela
local.import.remainsweb-of-science-index : Science Citation Index Expanded (SCI-EXPANDED)
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
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