A prospective multicentre screening study on multidrug-resistant organisms in intensive care units in the Dutch-German cross-border region, 2017 to 2018: the importance of healthcare structures
Autor(en): | Glasner, Corinna Berends, Matthijs S. Becker, Karsten Esser, Jutta Gieffers, Jens Jurke, Annette Kampinga, Greetje Kampmeier, Stefanie Klont, Rob Koeck, Robin von Mueller, Lutz Al Naemi, Nashwan Ott, Alewijn Ruijs, Gijs Saris, Katja Tami, Adriana Voss, Andreas Waar, Karola van Zeijl, Jan Friedrich, Alex W. |
Stichwörter: | ANTIMICROBIAL RESISTANCE; Infectious Diseases; OUTCOMES | Erscheinungsdatum: | 2022 | Herausgeber: | EUR CENTRE DIS PREVENTION & CONTROL | Journal: | EUROSURVEILLANCE | Volumen: | 27 | Ausgabe: | 5 | Zusammenfassung: | Background: Antimicrobial resistance poses a risk for healthcare, both in the community and hospitals. The spread of multidrug-resistant organisms (MDROs) occurs mostly on a local and regional level, following movement of patients, but also occurs across national borders. Aim: The aim of this observational study was to determine the prevalence of MDROs in a European cross-border region to understand differences and improve infection prevention based on real-time routine data and workflows. Methods: Between September 2017 and June 2018, 23 hospitals in the Dutch (NL)-German (DE) cross-border region (BR) par-ticipated in the study. During 8 consecutive weeks, patients were screened upon admission to intensive care units (ICUs) for nasal carriage of meticillin-resist-ant Staphylococcus aureus (MRSA) and rectal carriage of vancomycin-resistant Enterococcus faecium/E. faecalis (VRE), third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE) and carbapenem-resistant Enterobacteriaceae (CRE). All samples were processed in the associated laboratories. Results: A total of 3,365 patients were screened (median age: 68 years (IQR: 57-77); male/female ratio: 59.7/40.3; NL. BR: n = 1,202; DE-BR: n = 2,163). Median screening compliance was 60.4% (NI-BR: 56.9%; DE-BR: 62.9%). MDRO prevalence was higher in DE-BR than in NL-BR, namely 1.7% vs 0.6% for MRSA (p=0.006), 2.7% vs 0.1% for VRE (p<0.001) and 6.6% vs 3.6% for 3GCRE (p<0.001), whereas CRE prevalence was comparable (0.2% in DE-BR vs 0.0% in NL-BR ICUs). Conclusions: This first prospective multicentre screening study in a European cross-border region shows high heterogenicity in MDRO carriage prevalence in NL-BR and DE-BR ICUs. This indicates that the prevalence is probably influenced by the different healthcare structures. |
ISSN: | 1025-496X | DOI: | 10.2807/1560-7917.ES.2022.27.5.2001660 |
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geprüft am 20.05.2024