European patch test results with audit allergens as candidates for inclusion in the European Baseline Series, 2019/20: Joint results of the ESSCA(A) and the EBSB working groups of the ESCD, and the GEIDAC(C)

Autor(en): Uter, Wolfgang
Wilkinson, S. Mark
Aerts, Olivier
Bauer, Andrea
Borrego, Leopoldo
Buhl, Timo
Cooper, Susan M.
Dickel, Heinrich 
Gallo, Rosella
Gimenez-Arnau, Ana M.
John, Swen M. 
Navarini, Alexander A.
Pesonen, Maria
Ponyai, Gyorgyi
Rustemeyer, Thomas
Schliemann, Sibylle
Schubert, Steffen
Schuttelaar, Marie-Louise A.
Valiukeviciene, Skaidra
Wagner, Nicola
Weisshaar, Elke
Goncalo, Margarida
ESSCA Working Grp
EBS ESCD Working Grp
GEIDAC
Stichwörter: Allergy; baseline series; benzisothiazolinone; clinical epidemiology; contact allergy; CONTACT SENSITIZATION; decyl glucoside; Dermatology; LIMONENE; LINALOOL HYDROPEROXIDES; MIX; patch testing; RRID; SCR_001905; sodium metabisulfite; surveillance
Erscheinungsdatum: 2022
Herausgeber: WILEY
Enthalten in: CONTACT DERMATITIS
Band: 86
Ausgabe: 5
Startseite: 379
Seitenende: 389
Zusammenfassung: 
Background In 2019, a number of allergens (haptens), henceforth, ``the audit allergens,'' were considered as potential additions to the European Baseline Series (EBS), namely, sodium metabisulfite, 2-bromo-2-nitropropane-1,3-diol, diazolidinyl urea, imidazolidinyl urea, Compositae mix II (2.5% or 5% pet), linalool hydroperoxides (lin-OOH), limonene hydroperoxides (lim-OOH), benzisothiazolinone (BIT), octylisothiazolinone (OIT), decyl glucoside, and lauryl glucoside; Evernia furfuracea (tree moss), was additionally tested by some departments as well. Objectives To collect further data on patch test reactivity and clinical relevance of the audit allergens in consecutive patients across Europe. Methods Patch test data covering the audit allergens in 2019 and 2020 were collected by those departments of the European Surveillance System on Contact Allergies testing these, as well as further collaborators from the EBS working group of the European Society of Contact Dermatitis (ESCD), and the Spanish Grupo Espanol de Investigacion en Dermatitis de Contacto y Alergia Cutanea. As patch test outcome, reactions between day (D) 3 and D5 were considered. Results Altogether n = 12 403 patients were tested with any of the audit allergen. Positive reactions were most common to lin-OOH 1% pet. (8.74% [95%CI: 8.14-9.37%]), followed by lin-OOH 0.5% pet., and lim-OOH 0.3% pet (5.41% [95% CI: 4.95-5.89%]). Beyond these terpene hydroperoxides, BIT 0.1% pet. was the second most common allergen with 4.72% (95% CI: 4.2-5.28%), followed by sodium metabisulfite 1% pet. (3.75% [95%CI: 3.32-4.23%]) and Compositae mix 5% pet. (2.31% [95% CI: 1.84-2.87%]). For some allergens, clinical relevance was frequently difficult to ascertain. Conclusions Despite many positive patch test reactions, it remains controversial whether lin- and lim-OOH should be tested routinely, while at least the two preservatives BIT and sodium metabisulfite appear suitable. The present results are a basis for further discussion and ultimately decision on their implementation into routine testing among the ESCD members.
ISSN: 0105-1873
DOI: 10.1111/cod.14059

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