Fluorinated 7-deazapurine 2'-deoxyribonucleosides: Modification at the nucleobase and the sugar moiety
| Autor(en): | Seela, Frank Xu, Kuiying Chittepu, Padmaja Ming, Xin |
Stichwörter: | 7-IODO; base pairing; Biochemistry & Molecular Biology; DNA; fluorination; glycosylation; OLIGONUCLEOTIDES; pyrrolo[2,3-d]pyrimidine; sugar conformation | Erscheinungsdatum: | 2007 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 26 | Ausgabe: | 6-7 | Startseite: | 607 | Seitenende: | 610 | Zusammenfassung: | 7-Deaza-7-fluoro-purine 2'-deoxynucleosides as well as 2'-deoxy-2'-fluoroarabinofuranosyl nucleosides 1-8 were synthesized. The fluorine atom was introduced on the base level with Seleqfluor Nucleobase-anion glycosylation was then employed to form the nucleosides. Properties of the fluorine compounds were studied in solution and in solid state. Compound 4a was incorporated into oligonucleotides where the stabilizing effect was observed. |
Beschreibung: | Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006 |
ISSN: | 15257770 | DOI: | 10.1080/15257770701490357 |
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