7-halogenated 7-deaza-2 `-deoxyinosines

Autor(en): Ramzaeva, N
Mittelbach, C
Seela, F
Stichwörter: Chemistry; Chemistry, Multidisciplinary; DNA; NUCLEOSIDES; OLIGONUCLEOTIDES
Erscheinungsdatum: 1999
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: HELVETICA CHIMICA ACTA
Volumen: 82
Ausgabe: 1
Startseite: 12
Seitenende: 18
Zusammenfassung: 
The synthesis of the 7-deaza-2'-deoxyinosine derivatives 3a-c with chloro, bromo, and iodo substituents at position 7 is described. Glycosylation of the 7-halogenated 6-chloro-7-deazapurines 4a-c or of the 7-halogenated 6-chloro-7-deaza-2-(methylthio)purines 9a-c with 2-deoxy-3,5-di-O-(4-toluoyl)-alpha-D-erythro-pento-furanosyl chloride (5) furnished the intermediates 7a-c and 11a-c, respectively, which gave, upon deprotection, the desired nucleosides 3a-c.
ISSN: 0018019X
DOI: 10.1002/(SICI)1522-2675(19990113)82:1<12::AID-HLCA12>3.0.CO;2-L

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