Synthesis and Crystal Structures of Two 9-(2-Bromoethyl)-Substituted 7-Deazapurines

Autor(en): Asaftei, Simona
Reichelt, Martin
Reuter, Hans 
Rosemeyer, Helmut 
Stichwörter: ACYCLOGUANOSINE; Chemistry; Chemistry, Multidisciplinary; DERIVATIVES
Erscheinungsdatum: 2009
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: HELVETICA CHIMICA ACTA
Volumen: 92
Ausgabe: 10
Startseite: 1944
Seitenende: 1951
Zusammenfassung: 
The 7-(2-bromoethyl) derivatives, 2a and 2b, of 4-chloro-7H-pyrrolo[2,3-d]pyrimidine (1a) and 4-chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine (1b) were synthesized by nucleobase anion alkylation (NaH, DMF) and crystallized. X-Ray analyses of both compounds were performed, and they revealed significantly different positioning of the side chain relative to the heterocyclic ring, depending on the substituent (H or NH(2)) at C(2).
ISSN: 0018019X
DOI: 10.1002/hlca.200900145

Show full item record

Google ScholarTM

Check

Altmetric