The TRAIL to acne pathogenesis: let's focus on death pathways
| Autor(en): | Melnik, Bodo C. | Stichwörter: | acne; ACTIVATION; APOPTOSIS; c-FLIP; death signalling; Dermatology; FOXO; FoxOs; KERATINOCYTES; tumor necrosis factor-related apoptosis-inducing ligand | Erscheinungsdatum: | 2017 | Herausgeber: | WILEY | Journal: | EXPERIMENTAL DERMATOLOGY | Volumen: | 26 | Ausgabe: | 3 | Startseite: | 270 | Seitenende: | 272 | Zusammenfassung: | This hypothesis presents acne as a PI3K-Akt-mTORC1-driven pro-survival disease of the sebaceous follicle with impaired TRAIL-mediated death signalling. It is predicted that anti-acne agents such as isotretinoin enhance death signalling and thereby readjust the disturbed balance of pro-survival and death signalling of the sebaceous follicle in acne vulgaris. For this purpose, immortalized sebocyte cultures are regarded as inapproproate models to study the key features of acne pathogenesis. |
ISSN: | 09066705 | DOI: | 10.1111/exd.13169 |
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geprüft am 29.05.2024
