The TRAIL to acne pathogenesis: let's focus on death pathways

Autor(en): Melnik, Bodo C.
Stichwörter: acne; ACTIVATION; APOPTOSIS; c-FLIP; death signalling; Dermatology; FOXO; FoxOs; KERATINOCYTES; tumor necrosis factor-related apoptosis-inducing ligand
Erscheinungsdatum: 2017
Herausgeber: WILEY
Journal: EXPERIMENTAL DERMATOLOGY
Volumen: 26
Ausgabe: 3
Startseite: 270
Seitenende: 272
Zusammenfassung: 
This hypothesis presents acne as a PI3K-Akt-mTORC1-driven pro-survival disease of the sebaceous follicle with impaired TRAIL-mediated death signalling. It is predicted that anti-acne agents such as isotretinoin enhance death signalling and thereby readjust the disturbed balance of pro-survival and death signalling of the sebaceous follicle in acne vulgaris. For this purpose, immortalized sebocyte cultures are regarded as inapproproate models to study the key features of acne pathogenesis.
ISSN: 09066705
DOI: 10.1111/exd.13169

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