Interaction of viologens with nucleic acid G-tetrades

Autor(en): Asaftei, Simona
Rosemeyer, Helmut 
Walder, Lorenz 
Stichwörter: Chemistry; Chemistry, Multidisciplinary; Chemistry, Physical; Materials Science; Materials Science, Multidisciplinary
Erscheinungsdatum: 2008
Volumen: 24
Ausgabe: 11
Startseite: 5641
Seitenende: 5643
The interaction between the tetrade-forming oligonucleotide 5'-d(T(4)G(4)T(4)) and monoalkylated bipyridinium salts, such as 1-ethyl-4-pyridin-4-ylpyridinium bromide, is reported. The oligomer forms tetrades in the presence of K+ ions but not with Li+. Additionally, the interaction of the thrombin-binding aptamer 5'-d(GGTTGGTGTGGTTGG) (TBA) with a dialkylated bipyridinium salt, viologen, was studied by cyclic voltammetry. This was performed either on a TiO2 electrode, derivatized with 3-aminopropyltriethoxysilane (APS), using [Fe(CN)(6)](4-) as a marker ion or without a marker ion on an electrostatically TiO2-bound amino-ferrocenyl derivative. Both experiments proof a strong interaction between the immobilized aptamer and the viologen. Third, the electrochemical response of the specific thrombin binding to the immobilized aptamer was studied.
ISSN: 07437463
DOI: 10.1021/la704001n

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