7-deaza-2 `-deoxyxanthosine: Nucleobase protection and base pairing of oligonucleotides

DC FieldValueLanguage
dc.contributor.authorShaikh, Khalil I.
dc.contributor.authorLeonard, Peter
dc.contributor.authorSeela, Frank
dc.date.accessioned2021-12-23T16:05:30Z-
dc.date.available2021-12-23T16:05:30Z-
dc.date.issued2007
dc.identifier.issn15257770
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/7034-
dc.descriptionProceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006
dc.description.abstractOligonucleolides containing 7-deaza-2'-deoxyxanthosine (1) and 2'-deoxyxanthosine (2) were prepared. The 2-(4-nitrophenyl)ethyl group is applicable for 7-deazaxanthine protection that is removed with DBU by beta-elimination, while the deprotection of the allyl residue with Pd (0) catalyst failed. Contrarily, the allyl group was found to be an excellent Protecting group for 2'-deoxyxanthosine (2). The base pairing of nucleosides 1 and 2 with the four canonical DNA canstituents as well as with 3 within the 12-mer duplexes is studied.
dc.language.isoen
dc.publisherTAYLOR & FRANCIS INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.subject2'-deoxyxanthosine
dc.subject7-deaza-2'-deoxyxanthosine
dc.subjectbase pairing
dc.subjectBiochemistry & Molecular Biology
dc.subjectduplexes
dc.subjectGUANINE
dc.subjectNUCLEIC-ACIDS
dc.subjectNUCLEOTIDES
dc.subjectoligonucleotides
dc.subjectphosphoramidites
dc.subjectprotecting groups
dc.subjectXANTHINE
dc.title7-deaza-2 `-deoxyxanthosine: Nucleobase protection and base pairing of oligonucleotides
dc.typeconference paper
dc.identifier.doi10.1080/15257770701490837
dc.identifier.isiISI:000251875300042
dc.description.volume26
dc.description.issue6-7
dc.description.startpage737
dc.description.endpage741
dc.publisher.place325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USA
dcterms.isPartOf.abbreviationNucleosides Nucleotides Nucleic Acids
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