Gold DNA-conjugates: Ion specific self-assembly of gold nanoparticles via the dG-quartet
| Autor(en): | Seela, F Jawalekar, AM Chi, LF Zhong, DY Fuchs, H |
Stichwörter: | Biochemistry & Molecular Biology; DNA; G-quartet; gold-nanoparticles; QUADRUPLEX; self-assembly | Erscheinungsdatum: | 2005 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 24 | Ausgabe: | 5-7, SI | Startseite: | 843 | Seitenende: | 846 | Zusammenfassung: | The Oxytricha telomere DNA hairpin 5'-d(G(4)T(4)G(4)) immobilized on 13 nm gold nanoparticles forms a supramolecular assembly via dG-quartets, as determined by the color change and by SEM. The aggregation is ion-dependent and selective for sodium ions. K+ is less efficient while Li+ and Cs+ do not drive the aggregation. This work is the first effort exploring the use of secondary structures of DNA (quadruplexes) for producing self-assemblies of gold nanoparticles. |
Beschreibung: | 16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Univ Minnesota, Ctr Drug Design, Minneapolis, MN, SEP 12-16, 2004 |
ISSN: | 15257770 | DOI: | 10.1081/NCN-200060322 |
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