Membrane damage and repair: a thin line between life and death

DC FieldValueLanguage
dc.contributor.authorBarisch, Caroline
dc.contributor.authorHolthuis, Joost C. M.
dc.contributor.authorCosentino, Katia
dc.date.accessioned2023-07-12T06:54:06Z-
dc.date.available2023-07-12T06:54:06Z-
dc.date.issued2023
dc.identifier.issn1431-6730
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/71832-
dc.description.abstractBilayered membranes separate cells from their surroundings and form boundaries between intracellular organelles and the cytosol. Gated transport of solutes across membranes enables cells to establish vital ion gradients and a sophisticated metabolic network. However, an advanced compartmentalization of biochemical reactions makes cells also particularly vulnerable to membrane damage inflicted by pathogens, chemicals, inflammatory responses or mechanical stress. To avoid potentially lethal consequences of membrane injuries, cells continuously monitor the structural integrity of their membranes and readily activate appropriate pathways to plug, patch, engulf or shed the damaged membrane area. Here, we review recent insights into the cellular mechanisms that underly an effective maintenance of membrane integrity. We discuss how cells respond to membrane lesions caused by bacterial toxins and endogenous pore-forming proteins, with a primary focus on the intimate crosstalk between membrane proteins and lipids during wound formation, detection and elimination. We also discuss how a delicate balance between membrane damage and repair determines cell fate upon bacterial infection or activation of pro-inflammatory cell death pathways.
dc.description.sponsorshipDeutsche Forschungsgemeinschaft [SFB944-P14, SFB944-P25, SFB944-P26]; Acknowledgements We gratefully acknowledge the Deutsche Forschungsgemeinschaft for financial support of the work carried out in the laboratories of the authors (SFB944-P14 to J.H., SFB944-P25 to C.B., and SFB944-P26 to K.C.). C.B. is member of the SPP2225.
dc.language.isoen
dc.publisherWALTER DE GRUYTER GMBH
dc.relation.ispartofBIOLOGICAL CHEMISTRY
dc.subjectBiochemistry & Molecular Biology
dc.subjectcell death
dc.subjectCYTOTOXIC LYMPHOCYTES
dc.subjectDIPEPTIDYL PEPTIDASE-I
dc.subjectESCRT
dc.subjectGASDERMIN D
dc.subjectLEUCINE METHYL-ESTER
dc.subjectLIPID-PEROXIDATION
dc.subjectlysosome
dc.subjectMITOCHONDRIAL OUTER-MEMBRANE
dc.subjectMycobacterium tuberculosis
dc.subjectMYCOBACTERIUM-TUBERCULOSIS
dc.subjectPLASMA-MEMBRANE
dc.subjectPORE FORMATION
dc.subjectpore-forming proteins
dc.subjectSECRETION SYSTEMS
dc.subjectsphingomyelin
dc.titleMembrane damage and repair: a thin line between life and death
dc.typereview
dc.identifier.doi10.1515/hsz-2022-0321
dc.identifier.isiISI:000936489200001
dc.description.volume404
dc.description.issue5
dc.description.startpage467
dc.description.endpage490
dc.contributor.orcidhttp://orcid.org/0000-0002-3796-3500
dc.contributor.orcidhttp://orcid.org/0000-0002-1493-9006
dc.contributor.researcheridABG-8069-2020
dc.identifier.eissn1437-4315
dc.publisher.placeGENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
dcterms.isPartOf.abbreviationBiol. Chem.
dcterms.oaStatushybrid
local.import.remainsaffiliations : University Osnabruck; University Osnabruck; University Osnabruck; University Osnabruck
local.import.remainsearlyaccessdate : FEB 2023
local.import.remainsweb-of-science-index : Science Citation Index Expanded (SCI-EXPANDED)
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0002-1493-9006-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidBaCa878-
crisitem.author.netidCoKa893-
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