DC Field | Value | Language |
dc.contributor.author | Seela, Frank | |
dc.contributor.author | Sirivolu, Venkata Ramana | |
dc.date.accessioned | 2021-12-23T16:05:45Z | - |
dc.date.available | 2021-12-23T16:05:45Z | - |
dc.date.issued | 2006 | |
dc.identifier.issn | 16121872 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/7187 | - |
dc.description.abstract | The synthesis of a series of oligonucleotides containing 5-substituted pyrimidines as well as 7-substituted 7-deazapurines bearing diyne groups with terminal triple bonds is reported. The modified nucleosides were prepared from the corresponding iodo nucleosides and diynes by the Sonogashira cross-coupling reaction. They were converted into phosphoramidites and employed in solid-phase synthesis of oligonucleotides. The effect of the diyne modifications on the duplex stability was investigated. The modified nucleosides were used for further functionalization using the protocol of Huisgen-Sharpless [2 3] cycloaddition ('click chemistry'). | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | CHEMISTRY & BIODIVERSITY | |
dc.subject | ALKYNES | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | DUPLEX STABILITY | |
dc.subject | OLIGODEOXYNUCLEOTIDES | |
dc.subject | OLIGONUCLEOTIDES | |
dc.title | DNA containing side chains with terminal triple bonds: Base-pair stability and functionalization of alkynylated pyrimidines and 7-deazapurines | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/cbdv.200690054 | |
dc.identifier.isi | ISI:000238084000003 | |
dc.description.volume | 3 | |
dc.description.issue | 5 | |
dc.description.startpage | 509 | |
dc.description.endpage | 514 | |
dc.identifier.eissn | 16121880 | |
dc.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Chem. Biodivers. | |