DC Field | Value | Language |
dc.contributor.author | Babic, Zeljka | |
dc.contributor.author | Hallmann, Sarah | |
dc.contributor.author | Havmose, Martin S. | |
dc.contributor.author | Johansen, Jeanne D. | |
dc.contributor.author | John, Swen M. | |
dc.contributor.author | Symanzik, Cara | |
dc.contributor.author | Uter, Wolfgang | |
dc.contributor.author | Weinert, Patricia | |
dc.contributor.author | van der Molen, Henk F. | |
dc.contributor.author | Kezic, Sanja | |
dc.contributor.author | Macan, Jelena | |
dc.contributor.author | Turk, Rajka | |
dc.date.accessioned | 2023-07-12T06:57:21Z | - |
dc.date.available | 2023-07-12T06:57:21Z | - |
dc.date.issued | 2023 | |
dc.identifier.issn | 0960-3271 | |
dc.identifier.uri | http://osnascholar.ub.uni-osnabrueck.de/handle/unios/71980 | - |
dc.description.abstract | This systematic review, conducted according to the PRISMA guidelines, focuses on genotoxicity of oxidative hair dye precursors. The search for original papers published from 2000 to 2021 was performed in Medline, Web of Science, Cochrane registry, Scientific Committee on Consumer Safety of the European Commission and German MAK Commission opinions. Nine publications on genotoxicity of p-phenylenediamine (PPD) and toluene-2,5-diamine (p-toluylenediamine; PTD) were included, reporting results of 17 assays covering main genotoxicity endpoints. PPD and PTD were positive in bacterial mutation in vitro assay, and PPD tested positive also for somatic cell mutations in the Rodent Pig-a assay in vivo. Clastogenicity of PPD and PTD was revealed by in vitro chromosomal aberration assay. The alkaline comet assay in vitro showed DNA damage after PPD exposure, which was not confirmed in vivo, where PTD exhibited positive results. PPD induced micronucleus formation in vitro, and increased micronucleus frequencies in mice erythrocytes following high dose oral exposure in vivo. Based on the results of a limited number of data from the classical genotoxicity assay battery, this systematic review indicates genotoxic potential of hair dye precursors PPD and PTD, which may present an important health concern for consumers and in particular for professional hairdressers. | |
dc.description.sponsorship | European Commission, DG Employment, Social Affairs and Inclusion [VS/2019/0440]; The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: With the support of the European Commission, DG Employment, Social Affairs and Inclusion; VS/2019/0440 | |
dc.language.iso | en | |
dc.publisher | SAGE PUBLICATIONS LTD | |
dc.relation.ispartof | HUMAN & EXPERIMENTAL TOXICOLOGY | |
dc.subject | 5-diamine | |
dc.subject | APOPTOSIS | |
dc.subject | BLADDER-CANCER | |
dc.subject | COMET ASSAY | |
dc.subject | EXPOSURE | |
dc.subject | genotoxicity | |
dc.subject | Hair dyes | |
dc.subject | HAIRDRESSERS | |
dc.subject | IN-VIVO | |
dc.subject | INDUCED DNA-DAMAGE | |
dc.subject | mutagenicity | |
dc.subject | P-PHENYLENEDIAMINE | |
dc.subject | p-toluylenediamine | |
dc.subject | PARA-PHENYLENEDIAMINE | |
dc.subject | RISK | |
dc.subject | toluene-2 | |
dc.subject | Toxicology | |
dc.title | Genotoxicity of oxidative hair dye precursors: A systematic review | |
dc.type | review | |
dc.identifier.doi | 10.1177/09603271231159803 | |
dc.identifier.isi | ISI:000944073300001 | |
dc.description.volume | 42 | |
dc.contributor.orcid | http://orcid.org/0000-0002-4090-6726 | |
dc.identifier.eissn | 1477-0903 | |
dc.publisher.place | 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND | |
dcterms.isPartOf.abbreviation | Hum. Exp. Toxicol. | |
dcterms.oaStatus | Green Published, hybrid | |
local.import.remains | affiliations : Institute for Medical Research & Occupational Health (IMROH); University of Erlangen Nuremberg; University of Copenhagen; Herlev & Gentofte Hospital; University Osnabruck; University Osnabruck; University of Amsterdam; Vrije Universiteit Amsterdam; Institute for Medical Research & Occupational Health (IMROH) | |
local.import.remains | web-of-science-index : Science Citation Index Expanded (SCI-EXPANDED) | |
crisitem.author.orcid | 0000-0001-5406-9458 | - |
crisitem.author.netid | JoSw269 | - |