A Series of Non-Oxido Vi Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity

DC FieldValueLanguage
dc.contributor.authorBanerjee, Atanu
dc.contributor.authorPatra, Sushree Aradhana
dc.contributor.authorSahu, Gurunath
dc.contributor.authorSciortino, Giuseppe
dc.contributor.authorPisanu, Federico
dc.contributor.authorGarribba, Eugenio
dc.contributor.authorCarvalho, M. Fernanda N. N.
dc.contributor.authorCorreia, Isabel
dc.contributor.authorPessoa, Joao Costa
dc.contributor.authorReuter, Hans
dc.contributor.authorDinda, Rupam
dc.date.accessioned2023-07-12T06:57:24Z-
dc.date.available2023-07-12T06:57:24Z-
dc.date.issued2023
dc.identifier.issn0020-1669
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/71992-
dc.description.abstractA series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4 , are reported. All the synthesized non-oxido VIV compounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1-3 reveal that the mononuclear non-oxido VIV complexes show distorted octahedral (1 and 2) or trigonal prismatic (3) arrangement around the non-oxido VIV center. EPR and DFT data indicate the coexistence of mer and fac isomers in solution, and ESI-MS results suggest a partial oxidation of [VIV(L1-4)2] to [VV(L1-4)2]+ and [VVO2(L1-4)]-; therefore, all these three complexes are plausible active species. Complexes 1-4 interact with bovine serum albumin (BSA) with a moderate binding affinity, and docking calculations reveal non-covalent interactions with different regions of BSA, particularly with Tyr, Lys, Arg, and Thr residues. In vitro cytotoxic activity of all complexes is assayed against the HT-29 (colon cancer) and HeLa (cervical cancer) cells and compared with the NIH-3T3 (mouse embryonic fibroblast) normal cell line by MTT assay and DAPI staining. The results suggest that complexes 1-4 are cytotoxic in nature and induce cell death in the cancer cell lines by apoptosis and that a mixture of VIV, VV, and VVO2 species could be responsible for the biological activity.
dc.description.sponsorshipCSIR, Govt. of India; Centro de Quimica Estrutural - Portuguese funds from Fundacao para a Ciencia e a Tecnologia (FCT) [UIDB/00100/2020, UIDP/00100/2020, LA/P/2020]; Programa Operacional Regional de Lisboa 2020; Fondazione di Sardegna [FdS2017Garribba]; [01 (3073)/21/EMR-II]; R.D. thanks CSIR, Govt. of India [grant no. 01 (3073)/21/EMR-II], for funding this research. J.C.P., I.C., and F.C. thank Centro de Quimica Estrutural which is financed by Portuguese funds from Fundacao para a Ciencia e a Tecnologia (FCT), projects UIDB/00100/2020, UIDP/00100/2020, LA/P/2020, and Programa Operacional Regional de Lisboa 2020. E.G., G.S., and F.P. thank Fondazione di Sardegna (project FdS2017Garribba).
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofINORGANIC CHEMISTRY
dc.subject(VO)-O-IV COMPLEXES
dc.subjectANTITUMOR-ACTIVITY
dc.subjectBIOLOGICAL EVALUATION
dc.subjectCELLULAR UPTAKE
dc.subjectChemistry
dc.subjectChemistry, Inorganic & Nuclear
dc.subjectCRYSTAL-STRUCTURE
dc.subjectDIOXIDOVANADIUM(V) COMPLEXES
dc.subjectOXIDOVANADIUM(V) COMPLEXES
dc.subjectOXOVANADIUM(V) COMPLEXES
dc.subjectSERUM-ALBUMIN
dc.subjectVANADIUM(IV) COMPLEXES
dc.titleA Series of Non-Oxido Vi Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
dc.typejournal article
dc.identifier.doi10.1021/acs.inorgchem.3c00753
dc.identifier.isiISI:000986494700001
dc.description.volume62
dc.description.issue20
dc.description.startpage7932
dc.description.endpage7953
dc.contributor.orcidhttp://orcid.org/0000-0001-7096-4284
dc.contributor.orcidhttp://orcid.org/0000-0002-7229-5966
dc.contributor.orcidhttp://orcid.org/0000-0002-3978-9964
dc.contributor.researcheridAAH-6847-2021
dc.contributor.researcheridH-9078-2012
dc.identifier.eissn1520-510X
dc.publisher.place1155 16TH ST, NW, WASHINGTON, DC 20036 USA
dcterms.isPartOf.abbreviationInorg. Chem.
local.import.remainsaffiliations : National Institute of Technology (NIT System); National Institute of Technology Rourkela; Barcelona Institute of Science & Technology; Universitat Rovira i Virgili; Institute of Chemical Research of Catalonia; University of Sassari; Universidade de Lisboa; Universidade de Lisboa; Instituto Superior Tecnico; University Osnabruck
local.import.remainsearlyaccessdate : MAY 2023
local.import.remainsweb-of-science-index : Science Citation Index Expanded (SCI-EXPANDED)
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidReHa636-
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