A Series of Non-Oxido Vi Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity
DC Element | Wert | Sprache |
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dc.contributor.author | Banerjee, Atanu | |
dc.contributor.author | Patra, Sushree Aradhana | |
dc.contributor.author | Sahu, Gurunath | |
dc.contributor.author | Sciortino, Giuseppe | |
dc.contributor.author | Pisanu, Federico | |
dc.contributor.author | Garribba, Eugenio | |
dc.contributor.author | Carvalho, M. Fernanda N. N. | |
dc.contributor.author | Correia, Isabel | |
dc.contributor.author | Pessoa, Joao Costa | |
dc.contributor.author | Reuter, Hans | |
dc.contributor.author | Dinda, Rupam | |
dc.date.accessioned | 2023-07-12T06:57:24Z | - |
dc.date.available | 2023-07-12T06:57:24Z | - |
dc.date.issued | 2023 | |
dc.identifier.issn | 0020-1669 | |
dc.identifier.uri | http://osnascholar.ub.uni-osnabrueck.de/handle/unios/71992 | - |
dc.description.abstract | A series of mononuclear non-oxido vanadium(IV) complexes, [VIV(L1-4)2] (1-4), featuring tridentate bi-negative ONS chelating S-alkyl/aryl-substituted dithiocarbazate ligands H2L1-4 , are reported. All the synthesized non-oxido VIV compounds are characterized by elemental analysis, spectroscopy (IR, UV-vis, and EPR), ESI-MS, as well as electrochemical techniques (cyclic voltammetry). Single-crystal X-ray diffraction studies of 1-3 reveal that the mononuclear non-oxido VIV complexes show distorted octahedral (1 and 2) or trigonal prismatic (3) arrangement around the non-oxido VIV center. EPR and DFT data indicate the coexistence of mer and fac isomers in solution, and ESI-MS results suggest a partial oxidation of [VIV(L1-4)2] to [VV(L1-4)2]+ and [VVO2(L1-4)]-; therefore, all these three complexes are plausible active species. Complexes 1-4 interact with bovine serum albumin (BSA) with a moderate binding affinity, and docking calculations reveal non-covalent interactions with different regions of BSA, particularly with Tyr, Lys, Arg, and Thr residues. In vitro cytotoxic activity of all complexes is assayed against the HT-29 (colon cancer) and HeLa (cervical cancer) cells and compared with the NIH-3T3 (mouse embryonic fibroblast) normal cell line by MTT assay and DAPI staining. The results suggest that complexes 1-4 are cytotoxic in nature and induce cell death in the cancer cell lines by apoptosis and that a mixture of VIV, VV, and VVO2 species could be responsible for the biological activity. | |
dc.description.sponsorship | CSIR, Govt. of India; Centro de Quimica Estrutural - Portuguese funds from Fundacao para a Ciencia e a Tecnologia (FCT) [UIDB/00100/2020, UIDP/00100/2020, LA/P/2020]; Programa Operacional Regional de Lisboa 2020; Fondazione di Sardegna [FdS2017Garribba]; [01 (3073)/21/EMR-II]; R.D. thanks CSIR, Govt. of India [grant no. 01 (3073)/21/EMR-II], for funding this research. J.C.P., I.C., and F.C. thank Centro de Quimica Estrutural which is financed by Portuguese funds from Fundacao para a Ciencia e a Tecnologia (FCT), projects UIDB/00100/2020, UIDP/00100/2020, LA/P/2020, and Programa Operacional Regional de Lisboa 2020. E.G., G.S., and F.P. thank Fondazione di Sardegna (project FdS2017Garribba). | |
dc.language.iso | en | |
dc.publisher | AMER CHEMICAL SOC | |
dc.relation.ispartof | INORGANIC CHEMISTRY | |
dc.subject | (VO)-O-IV COMPLEXES | |
dc.subject | ANTITUMOR-ACTIVITY | |
dc.subject | BIOLOGICAL EVALUATION | |
dc.subject | CELLULAR UPTAKE | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Inorganic & Nuclear | |
dc.subject | CRYSTAL-STRUCTURE | |
dc.subject | DIOXIDOVANADIUM(V) COMPLEXES | |
dc.subject | OXIDOVANADIUM(V) COMPLEXES | |
dc.subject | OXOVANADIUM(V) COMPLEXES | |
dc.subject | SERUM-ALBUMIN | |
dc.subject | VANADIUM(IV) COMPLEXES | |
dc.title | A Series of Non-Oxido Vi Complexes of Dibasic ONS Donor Ligands: Solution Stability, Chemical Transformations, Protein Interactions, and Antiproliferative Activity | |
dc.type | journal article | |
dc.identifier.doi | 10.1021/acs.inorgchem.3c00753 | |
dc.identifier.isi | ISI:000986494700001 | |
dc.description.volume | 62 | |
dc.description.issue | 20 | |
dc.description.startpage | 7932 | |
dc.description.endpage | 7953 | |
dc.contributor.orcid | http://orcid.org/0000-0001-7096-4284 | |
dc.contributor.orcid | http://orcid.org/0000-0002-7229-5966 | |
dc.contributor.orcid | http://orcid.org/0000-0002-3978-9964 | |
dc.contributor.researcherid | AAH-6847-2021 | |
dc.contributor.researcherid | H-9078-2012 | |
dc.identifier.eissn | 1520-510X | |
dc.publisher.place | 1155 16TH ST, NW, WASHINGTON, DC 20036 USA | |
dcterms.isPartOf.abbreviation | Inorg. Chem. | |
local.import.remains | affiliations : National Institute of Technology (NIT System); National Institute of Technology Rourkela; Barcelona Institute of Science & Technology; Universitat Rovira i Virgili; Institute of Chemical Research of Catalonia; University of Sassari; Universidade de Lisboa; Universidade de Lisboa; Instituto Superior Tecnico; University Osnabruck | |
local.import.remains | earlyaccessdate : MAY 2023 | |
local.import.remains | web-of-science-index : Science Citation Index Expanded (SCI-EXPANDED) | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | ReHa636 | - |
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geprüft am 07.06.2024