Live Cell Imaging zeigt, wie Tau den axonalen Transport ausbremst

Abstract

Tau is a cytoskeletal protein that regulates microtubule polymerization in the axon. In diseases such as Alzheimer's disease, tau forms insoluble aggregates in the somatodendritic compartment. How tau regulates microtubule assembly without disrupting axonal transport and how tau dysfunction contributes to disease remains unclear. Here, we show how live cell imaging and super-resolution microscopy can help solve key questions about the physiological and pathological role of tau. © 2023, Die Autorinnen und Autoren.