Pyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Seela, F | |
dc.contributor.author | Zulauf, M | |
dc.contributor.author | Chen, SF | |
dc.date.accessioned | 2021-12-23T16:05:52Z | - |
dc.date.available | 2021-12-23T16:05:52Z | - |
dc.date.issued | 2000 | |
dc.identifier.issn | 15257770 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/7253 | - |
dc.description.abstract | A one step synthesis, using the nucleoside 7-iodo-2'-deoxytubercidin (2b) in a Pd(0)/Cu(I)-catalyzed cross coupling reaction furnished a series of 7-alkynyl-2'-deoxytubercidin derivatives. The 7-iodo-, 7-chloro- or 7-bromo 2'-deoxytubercidins 2b-d as well as certain 7-alkynyl derivatives show significant activity against several tumor cell lines, with 7-iodo-2'-deoxytubercidin (2b) as the most effective compound. | |
dc.language.iso | en | |
dc.publisher | MARCEL DEKKER INC | |
dc.relation.ispartof | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | |
dc.subject | ANTIVIRAL ACTIVITY | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | BIS-NAPHTHALIMIDE | |
dc.subject | DERIVATIVES | |
dc.subject | DNA | |
dc.subject | NUCLEOTIDES | |
dc.subject | OLIGODEOXYNUCLEOTIDES | |
dc.subject | OLIGONUCLEOTIDES | |
dc.subject | POTENT | |
dc.subject | PROPYNE ANALOGS | |
dc.subject | TOYOCAMYCIN | |
dc.title | Pyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines | |
dc.type | journal article | |
dc.identifier.doi | 10.1080/15257770008033006 | |
dc.identifier.isi | ISI:000086863600016 | |
dc.description.volume | 19 | |
dc.description.issue | 1-2 | |
dc.description.startpage | 237 | |
dc.description.endpage | 251 | |
dc.publisher.place | 270 MADISON AVE, NEW YORK, NY 10016 USA | |
dcterms.isPartOf.abbreviation | Nucleosides Nucleotides Nucleic Acids |
Seitenaufrufe
2
Letzte Woche
1
1
Letzter Monat
0
0
geprüft am 23.05.2024