Pyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines

DC ElementWertSprache
dc.contributor.authorSeela, F
dc.contributor.authorZulauf, M
dc.contributor.authorChen, SF
dc.date.accessioned2021-12-23T16:05:52Z-
dc.date.available2021-12-23T16:05:52Z-
dc.date.issued2000
dc.identifier.issn15257770
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/7253-
dc.description.abstractA one step synthesis, using the nucleoside 7-iodo-2'-deoxytubercidin (2b) in a Pd(0)/Cu(I)-catalyzed cross coupling reaction furnished a series of 7-alkynyl-2'-deoxytubercidin derivatives. The 7-iodo-, 7-chloro- or 7-bromo 2'-deoxytubercidins 2b-d as well as certain 7-alkynyl derivatives show significant activity against several tumor cell lines, with 7-iodo-2'-deoxytubercidin (2b) as the most effective compound.
dc.language.isoen
dc.publisherMARCEL DEKKER INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.subjectANTIVIRAL ACTIVITY
dc.subjectBiochemistry & Molecular Biology
dc.subjectBIS-NAPHTHALIMIDE
dc.subjectDERIVATIVES
dc.subjectDNA
dc.subjectNUCLEOTIDES
dc.subjectOLIGODEOXYNUCLEOTIDES
dc.subjectOLIGONUCLEOTIDES
dc.subjectPOTENT
dc.subjectPROPYNE ANALOGS
dc.subjectTOYOCAMYCIN
dc.titlePyrrolo[2,3-d]pyrimidine nucleosides: Synthesis and antitumor activity of 7-substituted 7-deaza-2 `-deoxyadenosines
dc.typejournal article
dc.identifier.doi10.1080/15257770008033006
dc.identifier.isiISI:000086863600016
dc.description.volume19
dc.description.issue1-2
dc.description.startpage237
dc.description.endpage251
dc.publisher.place270 MADISON AVE, NEW YORK, NY 10016 USA
dcterms.isPartOf.abbreviationNucleosides Nucleotides Nucleic Acids
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