Mechanisms of Nonvesicular Ceramide Transport

DC FieldValueLanguage
dc.contributor.authorClausmeyer, Lena
dc.contributor.authorFröhlich, Florian
dc.date.accessioned2024-01-04T10:28:53Z-
dc.date.available2024-01-04T10:28:53Z-
dc.date.issued2023
dc.identifier.issn2515-2564
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/72921-
dc.descriptionCited by: 0; All Open Access, Gold Open Access
dc.description.abstractCeramides, as key components of cellular membranes, play essential roles in various cellular processes, including apoptosis, cell proliferation, and cell signaling. Ceramides are the precursors of all complex sphingolipids in eukaryotic cells. They are synthesized in the endoplasmic reticulum and are further processed at the Golgi apparatus. Therefore, ceramides have to be transported between these two organelles. In mammalian cells, the ceramide transfer protein forms a contact site between the ER and the trans-Golgi region and transports ceramide utilizing its steroidogenic acute regulatory protein-related lipid transfer domain. In yeast, multiple mechanisms of nonvesicular ceramide transport have been described. This involves the nuclear–vacuolar junction protein Nvj2, the yeast tricalbin proteins, and the lipocalin-like protein Svf1. This review aims to provide a comprehensive overview of nonvesicular ceramide transport mechanisms and their relevance in cellular physiology. We will highlight the physiological and pathological consequences of perturbations in nonvesicular ceramide transport and discuss future challenges in identifying and analyzing ceramide transfer proteins. © The Author(s) 2023.
dc.language.isoen
dc.publisherSAGE Publications Inc.
dc.relation.ispartofContact
dc.subjectceramide
dc.subjectceramide transport protein
dc.subjectNvj2
dc.subjectSvf1
dc.subjecttransport
dc.subjecttricalbins
dc.titleMechanisms of Nonvesicular Ceramide Transport
dc.typereview
dc.identifier.doi10.1177/25152564231208250
dc.identifier.scopus2-s2.0-85174730836
dc.identifier.urlhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-85174730836&doi=10.1177%2f25152564231208250&partnerID=40&md5=fee74e7e2e18ae2658450298c2251d08
dc.description.volume6
dcterms.isPartOf.abbreviationContact
local.import.remainsaffiliations : Department of Biology/Chemistry, Bioanalytical Chemistry Section, Osnabrück University, Osnabrück, Germany; Center of Cellular Nanoanalytics Osnabrück (CellNanOs), Osnabrück University, Osnabrück, Germany
local.import.remainscorrespondence_address : F. Fröhlich; Department of Biology/Chemistry, Bioanalytical Chemistry Section, Osnabrück University, Osnabrück, Germany; email: florian.froehlich@uos.de
local.import.remainspublication_stage : Final
crisitem.author.deptSonderforschungsbereich 944: Physiologie und Dynamik zellulärer Mikrokompartimente-
crisitem.author.deptidorganisation19-
crisitem.author.orcid0000-0001-8307-2189-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidFrFl166-
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