Liquid-Gated Graphene Field-Effect Transistors for Biosensing on Lipid Monolayers
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Fomin, Mykola | |
dc.contributor.author | Jorde, Lara | |
dc.contributor.author | Steinbach, Florian | |
dc.contributor.author | You, Changjiang | |
dc.contributor.author | Meyer, Carola | |
dc.date.accessioned | 2024-01-04T10:30:59Z | - |
dc.date.available | 2024-01-04T10:30:59Z | - |
dc.date.issued | 2023 | |
dc.identifier.issn | 0370-1972 | |
dc.identifier.uri | http://osnascholar.ub.uni-osnabrueck.de/handle/unios/72995 | - |
dc.description.abstract | This study presents a comprehensive fabrication process for high-quality graphene field-effect transistors (GFETs) and their characterization. It is demonstrated that the suggested cost-efficient method of fabrication utilizing the direct-laser writing (DLW) system is reliable and ensures lower contact resistance between graphene and metal compared to other works. This improvement results in minimal signal loss and distortion, providing significant benefits to the overall performance of the GFETs. The fabricated devices are functionalized with a lipid monolayer containing tris-nitrilotriacetic acid fused to the lipids for the binding of histidine-tagged proteins. Monomeric enhanced green fluorescent protein (GFP) is used as a model protein to explore the current-voltage characteristics response of the liquid-gated GFETs. The results demonstrate that the devices are well suited for the electrical biosensing of proteins in physiological buffer conditions, paving the way for label-free detection of protein-protein interactions at membranes. This study presents a fabrication process for high-quality graphene field-effect transistors. The fabricated devices are functionalized with a lipid monolayer containing tris-nitrilotriacetic acid fused to the lipids to bind histidine-tagged proteins. The results demonstrate that the devices are well suited for the electrical biosensing of proteins in physiological buffer conditions, paving the way for label-free detection at lipid monolayers.image (c) 2023 WILEY-VCH GmbH | |
dc.description.sponsorship | Open Access funding enabled and organized by Projekt DEAL.; The authors thank Annette Budke-Gieseking for expert technical assistance on protein preparation. This project was supported by intramural funding from Osnabrueck University (Profile line ``Integrated Science'') and by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) - INST 190/190-1 FUGG.Open Access funding enabled and organized by Projekt DEAL.r Open Access funding enabled and organized by Projekt DEAL. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | PHYSICA STATUS SOLIDI B-BASIC SOLID STATE PHYSICS | |
dc.subject | BINDING | |
dc.subject | biofunctionalization | |
dc.subject | CONTACT RESISTANCE | |
dc.subject | DYNAMICS | |
dc.subject | graphene field-effect transistors | |
dc.subject | label-free biosensing | |
dc.subject | membrane proteins | |
dc.subject | NOISE | |
dc.subject | Physics | |
dc.subject | Physics, Condensed Matter | |
dc.subject | protein-protein interactions | |
dc.subject | PROTEINS | |
dc.subject | STOICHIOMETRY | |
dc.subject | TRANSPORT | |
dc.title | Liquid-Gated Graphene Field-Effect Transistors for Biosensing on Lipid Monolayers | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/pssb.202300324 | |
dc.identifier.isi | ISI:001092704500001 | |
dc.identifier.eissn | 1521-3951 | |
dc.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Phys. Status Solidi B-Basic Solid State Phys. | |
dcterms.oaStatus | Bronze | |
local.import.remains | affiliations : University Osnabruck; University Osnabruck; University Osnabruck | |
local.import.remains | earlyaccessdate : NOV 2023 | |
local.import.remains | web-of-science-index : Science Citation Index Expanded (SCI-EXPANDED) | |
crisitem.author.dept | Sonderforschungsbereich 944: Physiologie und Dynamik zellulärer Mikrokompartimente | - |
crisitem.author.dept | FB 04 - Physik | - |
crisitem.author.deptid | organisation19 | - |
crisitem.author.deptid | fb04 | - |
crisitem.author.orcid | 0000-0002-7839-6397 | - |
crisitem.author.orcid | 0000-0003-0851-2767 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | YoCh745 | - |
crisitem.author.netid | MeCa197 | - |
Seitenaufrufe
3
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 28.05.2024