INACTIVATION OF FUSIDIC ACID BY RESISTANT STREPTOMYCES STRAINS

DC ElementWertSprache
dc.contributor.authorVONDERHAAR, B
dc.contributor.authorROSENBERG, D
dc.contributor.authorDITTRICH, W
dc.contributor.authorSCHREMPF, H
dc.date.accessioned2021-12-23T16:06:11Z-
dc.date.available2021-12-23T16:06:11Z-
dc.date.issued1991
dc.identifier.issn00218820
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/7305-
dc.description.abstractStreptomyces lividans and several other Streptomyces species are resistant to the steroid-like antibiotic fusidic acid. This resistance is mediated by structural modification of the antibiotic. Using TLC, CD, UV, IR, NMR and mass spectroscopy the structure of one of the resulting inactive compounds was determined. It is derived from fusidic acid by the loss of an acetyl group and the formation of a lactone ring between C-21 and C-16. In addition, helvolic acid, a compound closely related to fusidic acid, has been shown to be modified.
dc.language.isoen
dc.publisherJAPAN ANTIBIOT RES ASSN
dc.relation.ispartofJOURNAL OF ANTIBIOTICS
dc.subjectBiotechnology & Applied Microbiology
dc.subjectImmunology
dc.subjectMicrobiology
dc.subjectPharmacology & Pharmacy
dc.titleINACTIVATION OF FUSIDIC ACID BY RESISTANT STREPTOMYCES STRAINS
dc.typejournal article
dc.identifier.isiISI:A1991GC28400012
dc.description.volume44
dc.description.issue7
dc.description.startpage785
dc.description.endpage792
dc.publisher.place2 20 8 KAMIOSAKI SHINAGAWA KU, TOKYO 141, JAPAN
dcterms.isPartOf.abbreviationJ. Antibiot.
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidScHi752-
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