Anomeric and Enantiomeric 2'-Deoxycytidines: Base Pair Stability in the Absence and Presence of Silver Ions

Autor(en): Zhang, Aigui
Budow-Busse, Simone
Leonard, Peter
Seela, Frank
Stichwörter: ALPHA-OLIGODEOXYNUCLEOTIDES; anomers; BINDING; Chemistry; Chemistry, Multidisciplinary; deoxycytidine; DNA duplexes; enantiomers; HETEROCHIRAL DNA; METAL-IONS; NMR; NUCLEIC-ACID; NUCLEOSIDES; OLIGONUCLEOTIDES; RECOGNITION; silver
Erscheinungsdatum: 2021
Herausgeber: WILEY-V C H VERLAG GMBH
Journal: CHEMISTRY-A EUROPEAN JOURNAL
Volumen: 27
Ausgabe: 41
Startseite: 10574
Seitenende: 10577
Zusammenfassung: 
Dodecamer duplex DNA containing anomeric (alpha/beta-d) and enantiomeric (beta-l/beta-d) 2'-deoxycytidine mismatches was studied with respect to base pair stability in the absence and presence of silver ions. Stable duplexes with silver-mediated cytosine-cytosine pairs were formed by all anomeric and enantiomeric combinations. Stability changes were observed depending on the composition of the mismatches. Most strikingly, the new silver-mediated base pair of anomeric alpha-d-dC with enantiomeric beta-l-dC is superior to the well-noted beta-d/beta-d-dC pair in terms of stability. CD spectra were used to follow global helical changes of DNA structure.
ISSN: 09476539
DOI: 10.1002/chem.202101253

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