Anomeric and Enantiomeric 2'-Deoxycytidines: Base Pair Stability in the Absence and Presence of Silver Ions
| Autor(en): | Zhang, Aigui Budow-Busse, Simone Leonard, Peter Seela, Frank |
Stichwörter: | ALPHA-OLIGODEOXYNUCLEOTIDES; anomers; BINDING; Chemistry; Chemistry, Multidisciplinary; deoxycytidine; DNA duplexes; enantiomers; HETEROCHIRAL DNA; METAL-IONS; NMR; NUCLEIC-ACID; NUCLEOSIDES; OLIGONUCLEOTIDES; RECOGNITION; silver | Erscheinungsdatum: | 2021 | Herausgeber: | WILEY-V C H VERLAG GMBH | Enthalten in: | CHEMISTRY-A EUROPEAN JOURNAL | Band: | 27 | Ausgabe: | 41 | Startseite: | 10574 | Seitenende: | 10577 | Zusammenfassung: | Dodecamer duplex DNA containing anomeric (alpha/beta-d) and enantiomeric (beta-l/beta-d) 2'-deoxycytidine mismatches was studied with respect to base pair stability in the absence and presence of silver ions. Stable duplexes with silver-mediated cytosine-cytosine pairs were formed by all anomeric and enantiomeric combinations. Stability changes were observed depending on the composition of the mismatches. Most strikingly, the new silver-mediated base pair of anomeric alpha-d-dC with enantiomeric beta-l-dC is superior to the well-noted beta-d/beta-d-dC pair in terms of stability. CD spectra were used to follow global helical changes of DNA structure. |
ISSN: | 09476539 | DOI: | 10.1002/chem.202101253 |
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geprüft am 06.06.2024
