Mismatch discrimination of base-modified nucleic acids and their constituents: Non-Watson-Crick base pairing induced by tautomerization

Autor(en): Seela, Frank
Peng, Xiahua
Xu, Kuiying
Stichwörter: 7-deazapurines; 8-aza-7-deazapurines; ANTIPARALLEL CHAIN ORIENTATION; base pair discrimination; Biochemistry & Molecular Biology; DERIVATIVES; DNA; nucleosides; OLIGONUCLEOTIDE DUPLEXES; oligonucleotides; PARALLEL; tautomers
Erscheinungsdatum: 2007
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 26
Ausgabe: 10-12
Startseite: 1569
Seitenende: 1572
Zusammenfassung: 
The effect of tautomerism on the mismatch discrimination was studied on 7-deazapurine and 8-aza-7-deazapurine analogues of isoguanosine. 7-Halogenated 7-deaza-2'-deoxyisoguanosines show better base pair discrimination than 2'-deoxyisoguanosine due to the more favored keto tautomer formation. 8-Aza-7-deazaisoguanosine and its 7-halogeno derivatives also show higher keto tautomer population than that of isoguanosine, but the 7-halogens do not bias the tautomeric equilibrium significantly as it is observed for the 7-deaza-2'-deoxyisoguanosine derivatives.
Beschreibung: 
Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006
ISSN: 15257770
DOI: 10.1080/15257770701547164

Show full item record

Page view(s)

3
Last Week
0
Last month
0
checked on Mar 2, 2024

Google ScholarTM

Check

Altmetric