Mismatch discrimination of base-modified nucleic acids and their constituents: Non-Watson-Crick base pairing induced by tautomerization
Autor(en): | Seela, Frank Peng, Xiahua Xu, Kuiying |
Stichwörter: | 7-deazapurines; 8-aza-7-deazapurines; ANTIPARALLEL CHAIN ORIENTATION; base pair discrimination; Biochemistry & Molecular Biology; DERIVATIVES; DNA; nucleosides; OLIGONUCLEOTIDE DUPLEXES; oligonucleotides; PARALLEL; tautomers | Erscheinungsdatum: | 2007 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 26 | Ausgabe: | 10-12 | Startseite: | 1569 | Seitenende: | 1572 | Zusammenfassung: | The effect of tautomerism on the mismatch discrimination was studied on 7-deazapurine and 8-aza-7-deazapurine analogues of isoguanosine. 7-Halogenated 7-deaza-2'-deoxyisoguanosines show better base pair discrimination than 2'-deoxyisoguanosine due to the more favored keto tautomer formation. 8-Aza-7-deazaisoguanosine and its 7-halogeno derivatives also show higher keto tautomer population than that of isoguanosine, but the 7-halogens do not bias the tautomeric equilibrium significantly as it is observed for the 7-deaza-2'-deoxyisoguanosine derivatives. |
Beschreibung: | Proceedings of the 17th International Roundtable of Nucleosides, Nucleotides, and Nucleic Acids, Bern, SWITZERLAND, MAR 07-SEP 07, 2006 |
ISSN: | 15257770 | DOI: | 10.1080/15257770701547164 |
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geprüft am 21.05.2024