Structure and regulation of insect plasma membrane H+V-ATPase

DC FieldValueLanguage
dc.contributor.authorWieczorek, H
dc.contributor.authorGrüber, G
dc.contributor.authorHarvey, WR
dc.contributor.authorHuss, M
dc.contributor.authorMerzendorfer, H
dc.contributor.authorZeiske, W
dc.date.accessioned2024-01-04T10:35:58Z-
dc.date.available2024-01-04T10:35:58Z-
dc.date.issued2000
dc.identifier.issn0022-0949
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/73223-
dc.description.abstractH+ V-ATPases (V-ATPases) are found in two principal locations, in endomembranes and in plasma membranes. The plasma membrane V-ATPase from the midgut of larval Manduca sexta is the sole energizer of all transepithelial secondary transport processes. At least two properties make the lepidopteran midgut a model tissue for studies of general aspects of V-ATPases. First, it is a rich source for purification of the enzyme and therefore for structural studies: 20 larvae provide up to 0.5 mg of holoenzyme, and soluble, cytosolic V-1 complexes can be obtained in even greater amounts off up to 2 mg, Second, midgut ion-tranport processes are strictly controlled by the regulation of the V-ATPase, which is the sole energizer of all ion transport in this epithelium. Recent advances in our understanding the structure of the V-1 and V-o complexes and of the regulation of the enzyme's biosynthesis and ion-transport activity will be discussed.
dc.description.sponsorshipNIAID NIH HHS [AI 22444] Funding Source: Medline
dc.language.isoen
dc.publisherCOMPANY OF BIOLOGISTS LTD
dc.relation.ispartofJOURNAL OF EXPERIMENTAL BIOLOGY
dc.subjectBiology
dc.subjectCRASSA VACUOLAR ATPASE
dc.subjectH+-translocating vacuolar-type ATPase
dc.subjectHORNWORM MANDUCA-SEXTA
dc.subjectLife Sciences & Biomedicine - Other Topics
dc.subjectMALPIGHIAN TUBULES
dc.subjectManduca sexta
dc.subjectMESSENGER-RNA
dc.subjectmidgut
dc.subjectMIDGUT EPITHELIUM
dc.subjectMITOCHONDRIA-RICH
dc.subjectPROTON PUMP
dc.subjectTOBACCO HORNWORM
dc.subjectTRANSCRIPTIONAL REGULATION
dc.subjectV-1 ATPase
dc.subjectV-1 complex
dc.subjectV-o complex
dc.subjectV-TYPE ATPASE
dc.titleStructure and regulation of insect plasma membrane H<SUP>+</SUP>V-ATPase
dc.typejournal article
dc.identifier.isiISI:000084963000015
dc.description.volume203
dc.description.issue1
dc.description.startpage127
dc.description.endpage135
dc.publisher.placeBIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND
dcterms.isPartOf.abbreviationJ. Exp. Biol.
local.import.remainsaffiliations : University Osnabruck; State University System of Florida; University of Florida
local.import.remainsweb-of-science-index : Science Citation Index Expanded (SCI-EXPANDED)
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptUniversität Osnabrück-
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.deptidfb05-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidWiHe990-
crisitem.author.netidHuMa001-
crisitem.author.netidMeHa731-
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