Membrane damage and repair: a thin line between life and death

DC FieldValueLanguage
dc.contributor.authorBarisch, Caroline
dc.contributor.authorHolthuis, Joost C. M.
dc.contributor.authorCosentino, Katia
dc.date.accessioned2024-01-04T14:08:16Z-
dc.date.available2024-01-04T14:08:16Z-
dc.date.issued2023
dc.identifier.issn1431-6730
dc.identifier.urihttp://osnascholar.ub.uni-osnabrueck.de/handle/unios/73323-
dc.description.abstractBilayered membranes separate cells from their surroundings and form boundaries between intracellular organelles and the cytosol. Gated transport of solutes across membranes enables cells to establish vital ion gradients and a sophisticated metabolic network. However, an advanced compartmentalization of biochemical reactions makes cells also particularly vulnerable to membrane damage inflicted by pathogens, chemicals, inflammatory responses or mechanical stress. To avoid potentially lethal consequences of membrane injuries, cells continuously monitor the structural integrity of their membranes and readily activate appropriate pathways to plug, patch, engulf or shed the damaged membrane area. Here, we review recent insights into the cellular mechanisms that underly an effective maintenance of membrane integrity. We discuss how cells respond to membrane lesions caused by bacterial toxins and endogenous pore-forming proteins, with a primary focus on the intimate crosstalk between membrane proteins and lipids during wound formation, detection and elimination. We also discuss how a delicate balance between membrane damage and repair determines cell fate upon bacterial infection or activation of pro-inflammatory cell death pathways.
dc.language.isoen
dc.relation.ispartofBiological chemistry
dc.sourcePubMed
dc.subject0 (Bacterial Toxins)
dc.subject0 (Lipids)
dc.subjectBacterial Toxins/metabolism
dc.subjectCell Membrane/metabolism
dc.subjectLipids/chemistry
dc.titleMembrane damage and repair: a thin line between life and death
dc.typejournal article
dc.identifier.doi10.1515/hsz-2022-0321
dc.identifier.pmid36810295
dc.contributor.affiliationMolecular Infection Biology Division, Department of Biology and Center of Cellular Nanoanalytics, Osnabrück University, D-49076 Osnabrück, Germany. Molecular Cell Biology Division, Department of Biology and Center of Cellular Nanoanalytics, Osnabrück University, D-49076 Osnabrück, Germany. Molecular Cell Biophysics Division, Department of Biology and Center of Cellular Nanoanalytics, Osnabrück University, D-49076 Osnabrück, Germany.
dc.description.volume404
dc.description.issue5
dc.description.startpage467
dc.description.endpage490
local.import.remainsU3 : Research Support, Non-U.S. Gov't
local.import.sourcefile./Barisch_Caroline_sk_Citavi_20231214.ris
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptFB 05 - Biologie/Chemie-
crisitem.author.deptidfb05-
crisitem.author.deptidfb05-
crisitem.author.orcid0000-0002-1493-9006-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.parentorgUniversität Osnabrück-
crisitem.author.netidBaCa878-
crisitem.author.netidCoKa893-
Show simple item record

Page view(s)

1
Last Week
0
Last month
0
checked on May 27, 2024

Google ScholarTM

Check

Altmetric