7-deazapurin-2,6-diamine and 7-deazaguanine: Synthesis and property of 7-substituted nucleosides and oligonucleotides
| Autor(en): | Seela, F Peng, XH Ming, X |
Stichwörter: | 7-deazapurine; 7-substituents; base-pairing; Biochemistry & Molecular Biology; nuclecisides; oligonucleotides | Erscheinungsdatum: | 2005 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 24 | Ausgabe: | 5-7, SI | Startseite: | 839 | Seitenende: | 841 | Zusammenfassung: | The synthesis of 7-substituted 7-deazaguanine and 7-deazaadenine ribonucleosides 1-2, the incorporation of 3a-d into oligonucleotides, and the stability of the corresponding duplexes and base discrimination are described. The pK(a), values of 3 - 4 are determined. |
Beschreibung: | 16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Univ Minnesota, Ctr Drug Design, Minneapolis, MN, SEP 12-16, 2004 |
ISSN: | 15257770 | DOI: | 10.1081/NCN-200060319 |
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