7-deazapurin-2,6-diamine and 7-deazaguanine: Synthesis and property of 7-substituted nucleosides and oligonucleotides

Autor(en): Seela, F
Peng, XH
Ming, X
Stichwörter: 7-deazapurine; 7-substituents; base-pairing; Biochemistry & Molecular Biology; nuclecisides; oligonucleotides
Erscheinungsdatum: 2005
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 24
Ausgabe: 5-7, SI
Startseite: 839
Seitenende: 841
Zusammenfassung: 
The synthesis of 7-substituted 7-deazaguanine and 7-deazaadenine ribonucleosides 1-2, the incorporation of 3a-d into oligonucleotides, and the stability of the corresponding duplexes and base discrimination are described. The pK(a), values of 3 - 4 are determined.
Beschreibung: 
16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Univ Minnesota, Ctr Drug Design, Minneapolis, MN, SEP 12-16, 2004
ISSN: 15257770
DOI: 10.1081/NCN-200060319

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