Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule regulation
| Autor(en): | Pinzi, Luca Conze, Christian Bisi, Nicolo Torre, Gabriele Dalla Monteiro-Abreu, Nanci Trushina, Nataliya I. Soliman, Ahmed Krusenbaum, Andrea Dolouei, Maryam Khodaei Hellwig, Andrea Christodoulou, Michael S. Passarella, Daniele Bakota, Lidia Rastelli, Giulio Brandt, Roland |
Stichwörter: | Tauopathy; Microtubule; Kinome; Tau protein; Neurodegeneration; Cell biology; Phosphorylation; Cyclin-dependent kinase 5; Neuroscience; Drug discovery; Chemistry; Biology; Alzheimer's disease; Biochemistry; Protein kinase A; Medicine; Disease; Cyclin-dependent kinase 2; Pathology | Erscheinungsdatum: | 2022 | DOI: | https://doi.org/10.1101/2022.10.31.514565 |
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