6-azapyrimidine and 7-deazapurine 2 `-deoxy-2 `-fluoroarabinonucleosides: Synthesis, conformation and properties of oligonucleotides
Autor(en): | Seela, F Chittepu, P He, Y He, JL Xu, KY |
Stichwörter: | Biochemistry & Molecular Biology; BIOLOGICAL-ACTIVITY; conformation; imide protection; solid-phase synthesis | Erscheinungsdatum: | 2005 | Herausgeber: | TAYLOR & FRANCIS INC | Journal: | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | Volumen: | 24 | Ausgabe: | 5-7, SI | Startseite: | 847 | Seitenende: | 850 | Zusammenfassung: | The synthesis of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl nucleasides (1b, 2b, and 3b) were described and their conformation in solution as well as in the solid state was determined. In addition to this, building blocks 10a,b and 13a,b were prepared and employed in solid-phase oh oligonucleotide synthesis. For compounds la and 1b the lactime proton is protected to avoid unresolved degradation of its phosphoramidites 10a,b. UV-melting studies have been carried out to assess the thermal stability of oligonucleotides containing compounds 1a,b, and 3a,b. |
Beschreibung: | 16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Univ Minnesota, Ctr Drug Design, Minneapolis, MN, SEP 12-16, 2004 |
ISSN: | 15257770 | DOI: | 10.1081/NCN-200059181 |
Zur Langanzeige
Seitenaufrufe
3
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 03.05.2024