6-azapyrimidine and 7-deazapurine 2 `-deoxy-2 `-fluoroarabinonucleosides: Synthesis, conformation and properties of oligonucleotides

Autor(en): Seela, F
Chittepu, P
He, Y
He, JL
Xu, KY
Stichwörter: Biochemistry & Molecular Biology; BIOLOGICAL-ACTIVITY; conformation; imide protection; solid-phase synthesis
Erscheinungsdatum: 2005
Herausgeber: TAYLOR & FRANCIS INC
Journal: NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
Volumen: 24
Ausgabe: 5-7, SI
Startseite: 847
Seitenende: 850
Zusammenfassung: 
The synthesis of 2'-deoxy-2'-fluoro-beta-D-arabinofuranosyl nucleasides (1b, 2b, and 3b) were described and their conformation in solution as well as in the solid state was determined. In addition to this, building blocks 10a,b and 13a,b were prepared and employed in solid-phase oh oligonucleotide synthesis. For compounds la and 1b the lactime proton is protected to avoid unresolved degradation of its phosphoramidites 10a,b. UV-melting studies have been carried out to assess the thermal stability of oligonucleotides containing compounds 1a,b, and 3a,b.
Beschreibung: 
16th International Roundtable of the International-Society-for-Nucleosides-Nucleotides-and-Nucleic-Acids (IS3NA), Univ Minnesota, Ctr Drug Design, Minneapolis, MN, SEP 12-16, 2004
ISSN: 15257770
DOI: 10.1081/NCN-200059181

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