1',5'-anhydrohexitol oligonucleotides: Synthesis, base pairing and recognition by regular oligodeoxyribonucleotides and oligoribonucleotides
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Hendrix, C | |
dc.contributor.author | Rosemeyer, H | |
dc.contributor.author | Verheggen, I | |
dc.contributor.author | Seela, F | |
dc.contributor.author | VanAerschot, A | |
dc.contributor.author | Herdewijn, P | |
dc.date.accessioned | 2021-12-23T16:06:52Z | - |
dc.date.available | 2021-12-23T16:06:52Z | - |
dc.date.issued | 1997 | |
dc.identifier.issn | 09476539 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/7592 | - |
dc.description.abstract | Oligonucleotides constructed of 1',5'-anhydrohexitol nucleoside building blocks (hexitol nucleic acids, HNA) are completely stable towards 3'-exonuclease and form very stable self-complementary duplexes as well as sequence-selective stable duplexes with the natural DNA and RNA, Triple-helix formation has also been observed, These hybridisation characteristics are highly dependent on the base sequence and the experimental conditions, When using a phosphate buffer containing 0.1M NaCl, a homopurine HNA dodecamer gives a Delta T-m of 1.3 degrees C/ base pair with DNA as complement and a Delta T-m of 3.0 degrees C/base pair with RNA as complement, These oligomers may therefore be of considerable interest as antisense constructs. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | CHEMISTRY-A EUROPEAN JOURNAL | |
dc.subject | 1,5-ANHYDROHEXITOL NUCLEOSIDES | |
dc.subject | ANALOGS | |
dc.subject | antisense systems | |
dc.subject | BINDING | |
dc.subject | BUILDING-BLOCKS | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Multidisciplinary | |
dc.subject | DNA recognition | |
dc.subject | ENZYMATIC STABILITY | |
dc.subject | HEXOSE-NUCLEIC-ACIDS | |
dc.subject | HOMO-DNA | |
dc.subject | HYBRIDIZATION | |
dc.subject | nucleic acids | |
dc.subject | OLIGODEOXYNUCLEOTIDES | |
dc.subject | oligonucleotides | |
dc.subject | RNA | |
dc.subject | SOLID-PHASE SYNTHESIS | |
dc.title | 1',5'-anhydrohexitol oligonucleotides: Synthesis, base pairing and recognition by regular oligodeoxyribonucleotides and oligoribonucleotides | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/chem.19970030118 | |
dc.identifier.isi | ISI:A1997WW25200015 | |
dc.description.volume | 3 | |
dc.description.issue | 1 | |
dc.description.startpage | 110 | |
dc.description.endpage | 120 | |
dc.contributor.orcid | 0000-0003-3528-8588 | |
dc.contributor.orcid | 0000-0003-3589-8503 | |
dc.identifier.eissn | 15213765 | |
dc.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Chem.-Eur. J. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | RoHe783 | - |
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