NEURONAL AND GLIAL GAMMA-AMINOBUTYRIC ACID+ TRANSPORTERS ARE DISTINCT PROTEINS

Autor(en): MABJEESH, NJ
FRESE, M
RAUEN, T
JESERICH, G
KANNER, BI
Stichwörter: ASTROGLIAL CELL; Biochemistry & Molecular Biology; Biophysics; Cell Biology; GABA TRANSPORT; GABA TRANSPORTER; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; MEMBRANE VESICLE; MEMBRANE-VESICLES; RAT-BRAIN; RECONSTITUTED PREPARATIONS; SEQUENCE DIRECTED ANTIBODY; SODIUM; SYSTEM
Erscheinungsdatum: 1992
Herausgeber: ELSEVIER SCIENCE BV
Journal: FEBS LETTERS
Volumen: 299
Ausgabe: 1
Startseite: 99
Seitenende: 102
Zusammenfassung: 
In the central nervous system, two subtypes of sodium- and chloride-coupled GABA transporter exist. One is sensitive to ACHC, the other to beta-alanine. They are thought to be of neuronal and glial origin, respectively. GABA transport in membrane vesicles derived from astroglial cells was found to be sodium- and chloride-dependent, electrogenic and much more sensitive to beta-alanine than to ACHC. Immunoblotting with antibodies directed against a variety of sequences of the ACHC-sensitive transporter indicated that none of these epitopes was shared by the glial transporter.
ISSN: 00145793
DOI: 10.1016/0014-5793(92)80109-T

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