Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity

DC FieldValueLanguage
dc.contributor.authorWang, J
dc.contributor.authorVerbeure, B
dc.contributor.authorLuyten, I
dc.contributor.authorFroeyen, M
dc.contributor.authorHendrix, C
dc.contributor.authorRosemeyer, H
dc.contributor.authorSeela, F
dc.contributor.authorVan Aerschot, A
dc.contributor.authorHerdewijn, P
dc.date.accessioned2021-12-23T16:07:02Z-
dc.date.available2021-12-23T16:07:02Z-
dc.date.issued2001
dc.identifier.issn15257770
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/7670-
dc.descriptionXIVth International Roundtable on Nucleosides, Nucleotides and their Biological Applications, SAN FRANCISCO, CALIFORNIA, SEP 10-14, 2000
dc.description.abstractCyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand.
dc.language.isoen
dc.publisherMARCEL DEKKER INC
dc.relation.ispartofNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
dc.subjectBiochemistry & Molecular Biology
dc.subjectOLIGONUCLEOTIDES
dc.titleCyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity
dc.typeconference paper
dc.identifier.doi10.1081/NCN-100002430
dc.identifier.isiISI:000170690500078
dc.description.volume20
dc.description.issue4-7
dc.description.startpage785
dc.description.endpage788
dc.contributor.orcid0000-0002-8675-6540
dc.contributor.orcid0000-0003-3589-8503
dc.contributor.orcid0000-0003-3528-8588
dc.contributor.researcheridI-1665-2014
dc.publisher.place270 MADISON AVE, NEW YORK, NY 10016 USA
dcterms.isPartOf.abbreviationNucleosides Nucleotides Nucleic Acids
crisitem.author.deptInstitut für Chemie neuer Materialien-
crisitem.author.deptidinstitute11-
crisitem.author.parentorgFB 05 - Biologie/Chemie-
crisitem.author.grandparentorgUniversität Osnabrück-
crisitem.author.netidRoHe783-
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