Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Wang, J | |
dc.contributor.author | Verbeure, B | |
dc.contributor.author | Luyten, I | |
dc.contributor.author | Froeyen, M | |
dc.contributor.author | Hendrix, C | |
dc.contributor.author | Rosemeyer, H | |
dc.contributor.author | Seela, F | |
dc.contributor.author | Van Aerschot, A | |
dc.contributor.author | Herdewijn, P | |
dc.date.accessioned | 2021-12-23T16:07:02Z | - |
dc.date.available | 2021-12-23T16:07:02Z | - |
dc.date.issued | 2001 | |
dc.identifier.issn | 15257770 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/7670 | - |
dc.description | XIVth International Roundtable on Nucleosides, Nucleotides and their Biological Applications, SAN FRANCISCO, CALIFORNIA, SEP 10-14, 2000 | |
dc.description.abstract | Cyclohexene nucleic acids (CeNA) were synthesized using classical phosporamidite chemistry. Incorporation of a cyclohexene nucleo-side in a DNA chain leads to an increase in stability of the DNA/RNA duplex. CeNA is stable against degradation in serum. A CeNA/RNA hybrid is able to activate E. Coli RNase H, resulting in cleavage of the RNA strand. | |
dc.language.iso | en | |
dc.publisher | MARCEL DEKKER INC | |
dc.relation.ispartof | NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | |
dc.subject | Biochemistry & Molecular Biology | |
dc.subject | OLIGONUCLEOTIDES | |
dc.title | Cyclohexene nucleic acids (CeNA) form stable duplexes with RNA and induce RNase H activity | |
dc.type | conference paper | |
dc.identifier.doi | 10.1081/NCN-100002430 | |
dc.identifier.isi | ISI:000170690500078 | |
dc.description.volume | 20 | |
dc.description.issue | 4-7 | |
dc.description.startpage | 785 | |
dc.description.endpage | 788 | |
dc.contributor.orcid | 0000-0002-8675-6540 | |
dc.contributor.orcid | 0000-0003-3589-8503 | |
dc.contributor.orcid | 0000-0003-3528-8588 | |
dc.contributor.researcherid | I-1665-2014 | |
dc.publisher.place | 270 MADISON AVE, NEW YORK, NY 10016 USA | |
dcterms.isPartOf.abbreviation | Nucleosides Nucleotides Nucleic Acids | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | RoHe783 | - |
Seitenaufrufe
2
Letzte Woche
0
0
Letzter Monat
0
0
geprüft am 01.06.2024