Ag+-Mediated DNA Base Pairing: Extraordinarily Stable Pyrrolo-dC-Pyrrolo-dC Pairs Binding Two Silver Ions

Autor(en): Mei, Hui
Roehl, Ingo
Seela, Frank
Stichwörter: ARTIFICIAL DNA; Chemistry; Chemistry, Organic; COMPLEXES; CROSS-LINKING; DUPLEX DNA; FLUORESCENCE; HYBRIDIZATION; METAL-IONS; OLIGONUCLEOTIDES; REPLICATION; TRANSITION
Erscheinungsdatum: 2013
Herausgeber: AMER CHEMICAL SOC
Journal: JOURNAL OF ORGANIC CHEMISTRY
Volumen: 78
Ausgabe: 18
Startseite: 9457
Seitenende: 9463
Zusammenfassung: 
6-Substituted pyrrolo-dC-pyrrolo-dC mismatches selectively capture silver ions to form extraordinarily stable metal-mediated base pairs. One single modification in a 12-mer duplex causes a T-m increase of 36.0 degrees C relative to the metal-free mismatched duplex. Spectrophotometric titrations as well as ESI mass spectra confirmed the binding of two silver ions per base pair. The Ag+-mediated base pairs may permit the construction of metal-responsive DNA with a very high silver loading.
ISSN: 00223263
DOI: 10.1021/jo401109w

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