Ag+-Mediated DNA Base Pairing: Extraordinarily Stable Pyrrolo-dC-Pyrrolo-dC Pairs Binding Two Silver Ions
| Autor(en): | Mei, Hui Roehl, Ingo Seela, Frank |
Stichwörter: | ARTIFICIAL DNA; Chemistry; Chemistry, Organic; COMPLEXES; CROSS-LINKING; DUPLEX DNA; FLUORESCENCE; HYBRIDIZATION; METAL-IONS; OLIGONUCLEOTIDES; REPLICATION; TRANSITION | Erscheinungsdatum: | 2013 | Herausgeber: | AMER CHEMICAL SOC | Enthalten in: | JOURNAL OF ORGANIC CHEMISTRY | Band: | 78 | Ausgabe: | 18 | Startseite: | 9457 | Seitenende: | 9463 | Zusammenfassung: | 6-Substituted pyrrolo-dC-pyrrolo-dC mismatches selectively capture silver ions to form extraordinarily stable metal-mediated base pairs. One single modification in a 12-mer duplex causes a T-m increase of 36.0 degrees C relative to the metal-free mismatched duplex. Spectrophotometric titrations as well as ESI mass spectra confirmed the binding of two silver ions per base pair. The Ag+-mediated base pairs may permit the construction of metal-responsive DNA with a very high silver loading. |
ISSN: | 00223263 | DOI: | 10.1021/jo401109w |
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geprüft am 07.06.2024
