Silver Arrays Inside DNA Duplexes Constructed from Silver(I)-Mediated Pyrrolo-dC-Pyrrolo-dC Base Pairs

DC FieldValueLanguage
dc.contributor.authorMei, Hui
dc.contributor.authorYang, Haozhe
dc.contributor.authorRoehl, Ingo
dc.contributor.authorSeela, Frank
dc.date.accessioned2021-12-23T16:07:16Z-
dc.date.available2021-12-23T16:07:16Z-
dc.date.issued2014
dc.identifier.issn21926506
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/7795-
dc.description.abstractTuneable silver arrays inside DNA duplexes were constructed by multiple incorporations of pyrrolo-dC-pyrrolo-dC base pairs. A short array with six silver ions was built within a DNA template. The size and positioning of the array is programmable and depends on the incorporation site of the modified base pairs. Always two silver ions were captured by one pyrrolo-dC-pyrrolo-dC pair as confirmed by melting experiments, UV and fluorescence titration experiments as well as ESI mass spectra. The silver-mediated pyrrolo-dC-pyrrolo-dC base pairs with phenyl residues in the 6-position were significantly more stable than those containing methyl substitutions. The caged silver ions are released from duplex DNA by sodium iodide but not by chloride or bromide anions, thus indicating very high stability of the metal-DNA complex.
dc.description.sponsorshipChemBiotech, Munster, Germany; We thank Mr. N. Q. Tran for oligonucleotide synthesis and Dr. H. Letzel, Organisch-Chemisches Institut, Universitat Munster, Germany, for the measurement of MALDI mass spectra. We also thank Dr. P. Leonard and Dr. S. Budow-Busse for their continuous support throughout the preparation of the manuscript. Financial support by ChemBiotech, Munster, Germany, is highly appreciated.
dc.language.isoen
dc.publisherWILEY-V C H VERLAG GMBH
dc.relation.ispartofCHEMPLUSCHEM
dc.subjectARTIFICIAL DNA
dc.subjectBINDING
dc.subjectChemistry
dc.subjectChemistry, Multidisciplinary
dc.subjectCOMPLEXES
dc.subjectDESIGN
dc.subjectDNA
dc.subjectMETAL-IONS
dc.subjectmetal-mediated base pairs
dc.subjectpyrrolo-dC
dc.subjectsilver
dc.subjectsilver arrays
dc.titleSilver Arrays Inside DNA Duplexes Constructed from Silver(I)-Mediated Pyrrolo-dC-Pyrrolo-dC Base Pairs
dc.typejournal article
dc.identifier.doi10.1002/cplu.201402060
dc.identifier.isiISI:000339570300004
dc.description.volume79
dc.description.issue7
dc.description.startpage914
dc.description.endpage918
dc.contributor.orcid0000-0001-7350-0688
dc.contributor.researcheridAAL-1705-2020
dc.publisher.placeBOSCHSTRASSE 12, D-69469 WEINHEIM, GERMANY
dcterms.isPartOf.abbreviationChemPlusChem
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