SIMILARITIES AND DIFFERENCES BETWEEN FISH OLIGODENDROCYTES AND SCHWANN-CELLS IN-VITRO

Autor(en): BASTMEYER, M
JESERICH, G
STUERMER, CAO
Stichwörter: ADHESION MOLECULES; ADULT GOLDFISH; AXONAL REGENERATION; CELL ADHESION MOLECULES; CNS MYELIN; CRANIAL NERVES; GOLDFISH; GOLDFISH VISUAL-SYSTEM; MYELIN PROTEINS; N-CAM; NEURITE GROWTH; Neurosciences; Neurosciences & Neurology; NGF RECEPTOR; OPTIC NERVE/TRACT; OPTIC-NERVE TRACT; RETINAL GANGLION-CELLS; RETINOTECTAL PATHWAY
Erscheinungsdatum: 1994
Herausgeber: WILEY-LISS
Journal: GLIA
Volumen: 11
Ausgabe: 4
Startseite: 300
Seitenende: 314
Zusammenfassung: 
In light of the striking differences between oligodendrocytes of the optic nerve/tract of adult goldfish and their mammalian counterparts, a further characterization of goldfish oligodendrocytes was performed. A comparison with Schwann cells was included because fish optic nerve/tract-derived oligodendrocytes bear remarkable similarities to this type of glial cell. Fish optic nerve/tract-derived oligodendrocytes that had differentiated into 04 and 6D2-positive cells and thus expressed early myelin marker molecules were found to incorporate BrdU and to divide in vitro over a period of weeks. For the induction of more advanced markers of myelinogenesis such as the CNS-specific myelin protein 36K, oligodendrocytes required extensive contact with axons. Other agents, such as fetal calf or carp serum, substrate components, or forscolin failed, however, to induce 36K expression. 04/6D2-positive oligodendrocytes could be distinguished from fish 6D2-positive Schwann cells derived from cranial nerves by their antigenic phenotype: Schwann cells but not oligodendrocytes exhibited the low affinity NGF receptor. While both cell types carry the cell adhesion molecules NCAM, E 587 antigen, and the L2/HNK-1 epitope, only Schwann cells possess a further adhesion molecule, Neurolin. (C) 1994 Wiley-Liss, Inc.
ISSN: 08941491
DOI: 10.1002/glia.440110403

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