DC Field | Value | Language |
dc.contributor.author | Schreiber, Gideon | |
dc.contributor.author | Piehler, Jacob | |
dc.date.accessioned | 2021-12-23T16:07:37Z | - |
dc.date.available | 2021-12-23T16:07:37Z | - |
dc.date.issued | 2015 | |
dc.identifier.issn | 14714906 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/7972 | - |
dc.description.abstract | Type I interferons (IFNs) are best known for their role in innate immunity, but they are also involved in other functions including immunomodulation, restricting proliferation, cancer surveillance, and the regulation of the adaptive immune response. All these responses are mediated through the interaction with a single cell surface receptor, albeit at different ligand and receptor concentrations, ligand subtypes, and time of activation. Here we review the functional plasticity of IFN signaling from a quantitative perspective, showing how variations in different ingredients of the system lead to differential IFN responses and how cells tune the system to maximize efficiency while minimizing detrimental effects. We present a basic model wherein the integrated action of different feedback mechanisms can provide sufficient temporal control to differentially drive cellular decisions. | |
dc.description.sponsorship | Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB944]; I-CORE Program of the Planning and Budgeting Committee; Israel Science FoundationIsrael Science Foundation [1775/12]; United States-Israel Binational Science Foundation (BSF)US-Israel Binational Science Foundation [2011093]; Financial support by the Deutsche Forschungsgemeinschaft (SFB944) to J.P., the I-CORE Program of the Planning and Budgeting Committee and the Israel Science Foundation (Grant No 1775/12), and Grant No 2011093 from the United States-Israel Binational Science Foundation (BSF) to G.S. is gratefully acknowledged. | |
dc.language.iso | en | |
dc.publisher | ELSEVIER SCI LTD | |
dc.relation.ispartof | TRENDS IN IMMUNOLOGY | |
dc.subject | ACTIVATION | |
dc.subject | ALPHA RECEPTOR | |
dc.subject | BINDING-SITE | |
dc.subject | COMPLEX | |
dc.subject | DIMERIZATION | |
dc.subject | ERYTHROPOIETIN RECEPTOR | |
dc.subject | GROWTH-HORMONE RECEPTOR | |
dc.subject | IFN-ALPHA-2 REVEALS | |
dc.subject | Immunology | |
dc.subject | LIGAND | |
dc.subject | MUTATIONAL ANALYSIS | |
dc.title | The molecular basis for functional plasticity in type I interferon signaling | |
dc.type | review | |
dc.identifier.doi | 10.1016/j.it.2015.01.002 | |
dc.identifier.isi | ISI:000351967000003 | |
dc.description.volume | 36 | |
dc.description.issue | 3 | |
dc.description.startpage | 139 | |
dc.description.endpage | 149 | |
dc.identifier.eissn | 14714981 | |
dc.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | |
dcterms.isPartOf.abbreviation | Trends Immunol. | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.orcid | 0000-0002-2143-2270 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | PiJa938 | - |