NUCLEOTIDE-SEQUENCE OF THE ILVH-FRUR GENE REGION OF ESCHERICHIA-COLI-K12 AND SALMONELLA-TYPHIMURIUM-LT2

Autor(en): JAHREIS, K
POSTMA, PW
LENGELER, JW
Stichwörter: Biochemistry & Molecular Biology; CLONING; COLI; EVOLUTIONARY RELATIONSHIP; FRU OPERON; FRUCTOSE PHOSPHOTRANSFERASE SYSTEM; FRUR REPRESSOR; Genetics & Heredity; ILVIH-PBPB; MOLECULAR-STRUCTURE; PEP; PSEUDO-HPR; SALMONELLA-TYPHIMURIUM; SHL GENE; SUCROSE METABOLISM; TRANSCRIPTION
Erscheinungsdatum: 1991
Herausgeber: SPRINGER VERLAG
Journal: MOLECULAR & GENERAL GENETICS
Volumen: 226
Ausgabe: 1-2
Startseite: 332
Seitenende: 336
Zusammenfassung: 
We have sequenced the fruR gene and flanking DNA fragments from Escherichia coli K12 and Salmonella typhimurium LT2. The fruR gene codes for a protein that represses the fru operon and activates the pps gene for PEP synthase. The corresponding open reading frame (ORF) FruR consists of 334 amino acid residues. The ORF contains an amino-terminal helix-turn-helix motif, characteristic of DNA-binding proteins and has similarity to known repressor proteins. The sequence is identical to that of the E. coli shl gene (mnemonic for suppressor-H-linked phenotype). It is flanked upstream by the ilvIH genes and downstream by the pbpB gene in both organisms and by orfB, a gene possibly involved in the regulation of cell division.
ISSN: 00268925
DOI: 10.1007/BF00273623

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