Autophagosome Maturation and Fusion

Autor(en): Reggiori, Fulvio
Ungermann, Christian 
Stichwörter: ATG protein; ATG8-PE DECONJUGATION; autophagosome; Biochemistry & Molecular Biology; CAENORHABDITIS-ELEGANS; HOMOTYPIC VACUOLE FUSION; HOPS TETHERING COMPLEX; lysosome; LYSOSOME FUSION; membrane fusion; PHOSPHATIDYLINOSITOL 3-PHOSPHATE; SACCHAROMYCES-CEREVISIAE; SELECTIVE AUTOPHAGY; SNARE; SNARE SYNTAXIN 17; VESICLE FORMATION
Erscheinungsdatum: 2017
Herausgeber: ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
Journal: JOURNAL OF MOLECULAR BIOLOGY
Volumen: 429
Ausgabe: 4
Startseite: 486
Seitenende: 496
Zusammenfassung: 
Macroautophagy, or simply autophagy, is a degradative pathway that delivers cytoplasmic components, including cytosol and organelles, to the lysosome in double-membrane vesicles called autophagosomes. This process is initiated at the pre-autophagosomal structure or phagophore assembly site and involves a number of highly conserved autophagy-related proteins. These support the generation and conversion of an open membranous cistern known as the phagophore or isolation membrane into a closed autophagosome. Within this review, we will focus on recent insights into the molecular events following the sealing/completion of an autophagosome, which lead to its maturation and subsequent fusion with endosomes/lysosomes. (C) 2017 The Authors. Published by Elsevier Ltd.
ISSN: 00222836
DOI: 10.1016/j.jmb.2017.01.002

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