Evaluation and Elucidation of DNA-Containing Viologen Dendrimer Complex Formation
DC Element | Wert | Sprache |
---|---|---|
dc.contributor.author | Bongard, Dirk | |
dc.contributor.author | Degefa, Tesfaye Hailu | |
dc.contributor.author | Schon, Peter | |
dc.contributor.author | Giese, Maria | |
dc.contributor.author | Brandt, Roland | |
dc.contributor.author | Walder, Lorenz | |
dc.date.accessioned | 2021-12-23T16:08:03Z | - |
dc.date.available | 2021-12-23T16:08:03Z | - |
dc.date.issued | 2016 | |
dc.identifier.issn | 1434193X | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/8207 | - |
dc.description.abstract | The syntheses of a tetracationic viologen and polycationic viologen dendrimers are described in this report. These water-soluble viologen dendrimers, the tetracationic viologen, and their DNA-containing complexes have been investigated by cyclic voltammetry (CV), electrophoresis, and atomic force microscopy with respect to their stability and effectiveness as possible transfection systems. The appearance of a negative potential shift and the loss of current in the cyclovoltammograms of viologen dendriplexes have been attributed to DNA/dendrimer complex formation. Oligomers of viologen with at least 4 positive charges are required for the formation of a primary DNA-viologen complex. The dynamics of the formation of a secondary complex was observed and studied by cyclic voltammetry. AFM measurements together with molecular modeling support the electrochemical results and show two different aggregates of the dendriplexes on gold. | |
dc.description.sponsorship | Interdisciplinary DFG Graduate College, Department of Biology/Chemistry, University of Osnabruck, Germany [612]; D. B. thanks the Interdisciplinary DFG Graduate College 612, Department of Biology/Chemistry, University of Osnabruck, Germany for a fellowship and for financial support. | |
dc.language.iso | en | |
dc.publisher | WILEY-V C H VERLAG GMBH | |
dc.relation.ispartof | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | |
dc.subject | AGENTS | |
dc.subject | ATOMIC-FORCE MICROSCOPY | |
dc.subject | Chemistry | |
dc.subject | Chemistry, Organic | |
dc.subject | Cyclic voltammetry | |
dc.subject | Dendrimers | |
dc.subject | Dendriplex formation | |
dc.subject | DNA | |
dc.subject | ELECTRON-TRANSFER | |
dc.subject | GENE DELIVERY | |
dc.subject | MECHANISM | |
dc.subject | MOLECULES | |
dc.subject | PHOSPHORUS DENDRIMERS | |
dc.subject | POLYMERS | |
dc.subject | SKELETON | |
dc.subject | Supramolecular chemistry | |
dc.subject | TRANSFECTION | |
dc.title | Evaluation and Elucidation of DNA-Containing Viologen Dendrimer Complex Formation | |
dc.type | journal article | |
dc.identifier.doi | 10.1002/ejoc.201501485 | |
dc.identifier.isi | ISI:000374148100015 | |
dc.description.volume | 2016 | |
dc.description.issue | 10 | |
dc.description.startpage | 1897 | |
dc.description.endpage | 1907 | |
dc.contributor.orcid | 0000-0002-5497-034X | |
dc.contributor.orcid | 0000-0003-0101-1257 | |
dc.identifier.eissn | 10990690 | |
dc.publisher.place | POSTFACH 101161, 69451 WEINHEIM, GERMANY | |
dcterms.isPartOf.abbreviation | Eur. J. Org. Chem. | |
crisitem.author.dept | Institut für Chemie neuer Materialien | - |
crisitem.author.deptid | institute11 | - |
crisitem.author.orcid | 0000-0003-0101-1257 | - |
crisitem.author.orcid | 0000-0002-5497-034X | - |
crisitem.author.parentorg | FB 05 - Biologie/Chemie | - |
crisitem.author.grandparentorg | Universität Osnabrück | - |
crisitem.author.netid | BrRo587 | - |
crisitem.author.netid | WaLo966 | - |
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geprüft am 01.06.2024