Yeast on the milky way: genetics, physiology and biotechnology of Kluyveromyces lactis

DC ElementWertSprache
dc.contributor.authorRodicio, Rosaura
dc.contributor.authorHeinisch, Juergen J.
dc.date.accessioned2021-12-23T16:08:05Z-
dc.date.available2021-12-23T16:08:05Z-
dc.date.issued2013
dc.identifier.issn0749503X
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8219-
dc.description.abstractThe milk yeast Kluyveromyces lactis has a life cycle similar to that of Saccharomyces cerevisiae and can be employed as a model eukaryote using classical genetics, such as the combination of desired traits, by crossing and tetrad analysis. Likewise, a growing set of vectors, marker cassettes and tags for fluorescence microscopy are available for manipulation by genetic engineering and investigating its basic cell biology. We here summarize these applications, as well as the current knowledge regarding its central metabolism, glucose and extracellular stress signalling pathways. A short overview on the biotechnological potential of K. lactis concludes this review. Copyright (c) 2013 John Wiley & Sons, Ltd.
dc.description.sponsorshipDeutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB 944]; MICINN, SpainSpanish Government [BFU2010-19628-C02-01]; We thank Dorthe Rippert for providing the TEM image of a budding K. lactis cell and Hans-Peter Schmitz for help in processing the DIC and fluorescence images. Both are members of J.J.H.'s group in Osnabruck, whose work is supported by a grant from the Deutsche Forschungsgemeinschaft within the framework of the SFB 944 to J.J.H. R.R. was supported by MICINN, Spain (Grant No. BFU2010-19628-C02-01).
dc.language.isoen
dc.publisherWILEY
dc.relation.ispartofYEAST
dc.subjectA SYNTHETASE GENES
dc.subjectACETYL-COENZYME
dc.subjectBETA-GALACTOSIDASE
dc.subjectBiochemistry & Molecular Biology
dc.subjectBiotechnology & Applied Microbiology
dc.subjectFUNCTIONAL-CHARACTERIZATION
dc.subjectglucose signalling
dc.subjectGLUCOSE-TRANSPORTER GENE
dc.subjectheterologous gene expression
dc.subjectISOCITRATE LYASE
dc.subjectlactose metabolism
dc.subjectMAPK signalling
dc.subjectMicrobiology
dc.subjectMOLECULAR-GENETICS
dc.subjectMycology
dc.subjectnon-Saccharomyces yeast
dc.subjectSACCHAROMYCES-CEREVISIAE
dc.subjectSIGNALING PATHWAY
dc.subjectTRANSCRIPTIONAL REGULATION
dc.titleYeast on the milky way: genetics, physiology and biotechnology of Kluyveromyces lactis
dc.typereview
dc.identifier.doi10.1002/yea.2954
dc.identifier.isiISI:000318949300001
dc.description.volume30
dc.description.issue5
dc.description.startpage165
dc.description.endpage177
dc.contributor.orcid0000-0002-3862-9619
dc.identifier.eissn10970061
dc.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dcterms.isPartOf.abbreviationYeast
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