Milk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?

DC FieldValueLanguage
dc.contributor.authorMelnik, Bodo C.
dc.contributor.authorJohn, Swen Malte
dc.contributor.authorSchmitz, Gerd
dc.date.accessioned2021-12-23T16:08:27Z-
dc.date.available2021-12-23T16:08:27Z-
dc.date.issued2014
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8302-
dc.description.abstractEpidemiological evidence confirmed that raw cow's milk consumption in the first year of life protects against the development of atopic diseases and increases the number of regulatory T-cells (Tregs). However, milk's atopy-protective mode of action remains elusive. This review supported by translational research proposes that milk-derived microRNAs (miRs) may represent the missing candidates that promote long-term lineage commitment of Tregs downregulating IL-4/Th2-mediated atopic sensitization and effector immune responses. Milk transfers exosomal miRs including the ancient miR-155, which is important for the development of the immune system and controls pivotal target genes involved in the regulation of FoxP3 expression, IL-4 signaling, immunoglobulin class switching to IgE and Fc epsilon RI expression. Boiling of milk abolishes milk's exosomal miR-mediated bioactivity. Infant formula in comparison to human breast- or cow's milk is deficient in bioactive exosomal miRs that may impair FoxP3 expression. The boost of milk-mediated miR may induce pivotal immunoregulatory and epigenetic modifications required for long-term thymic Treg lineage commitment explaining the atopy-protective effect of raw cow's milk consumption. The presented concept offers a new option for the prevention of atopic diseases by the addition of physiological amounts of miR-155-enriched exosomes to infant formula for mothers incapable of breastfeeding.
dc.language.isoen
dc.publisherBMC
dc.relation.ispartofJOURNAL OF TRANSLATIONAL MEDICINE
dc.subjectALDRICH-SYNDROME PROTEIN
dc.subjectAtopy prevention
dc.subjectC-MAF
dc.subjectCHILDHOOD ASTHMA
dc.subjectDNA demethylation
dc.subjectDNA HYPOMETHYLATION
dc.subjectExosome
dc.subjectEXTRACELLULAR VESICLES
dc.subjectFoxP3
dc.subjectFOXP3 EXPRESSION
dc.subjectIMMUNE-RELATED MICRORNAS
dc.subjectINNATE IMMUNITY
dc.subjectMedicine, Research & Experimental
dc.subjectMicroRNA
dc.subjectMilk
dc.subjectMiR-155
dc.subjectNF-KAPPA-B
dc.subjectRegulatory T cell
dc.subjectResearch & Experimental Medicine
dc.subjectTARGET GENES
dc.titleMilk: an exosomal microRNA transmitter promoting thymic regulatory T cell maturation preventing the development of atopy?
dc.typereview
dc.identifier.doi10.1186/1479-5876-12-43
dc.identifier.isiISI:000335531700001
dc.description.volume12
dc.contributor.orcid0000-0002-1325-1007
dc.identifier.eissn14795876
dc.publisher.placeCAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
dcterms.isPartOf.abbreviationJ. Transl. Med.
dcterms.oaStatusGreen Published, gold
crisitem.author.orcid0000-0001-5406-9458-
crisitem.author.netidJoSw269-
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