``Viologen'' Dendrimers as Antiviral Agents: The Effect of Charge Number and Distance

DC FieldValueLanguage
dc.contributor.authorAsaftei, Simona
dc.contributor.authorDe Clercq, Erik
dc.date.accessioned2021-12-23T16:08:29Z-
dc.date.available2021-12-23T16:08:29Z-
dc.date.issued2010
dc.identifier.issn00222623
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8313-
dc.description.abstractA series of ``viologen'' derivatives (4,4'-bipyridinium salts) carrying between 1 and 90 charges per molecule have been prepared and investigated for their activity against human immunodeficiency virus (HIV), herpes simplex virus (HSV), vesicular stomatitis, Punta Toro virus, Sindbis virus, Reovirus, and respiratory syncytial viruses. In general, most of the compounds showed good activities against HIV-1 (strain IIIB). In particular, compound 36 exhibited the highest in vitro activity and selectivity index against HIV-1 (strain IIIB) (EC50 = 0.26 /- 0.08 mu M, SI = 75.7) in MT-4 cells. The results imply that the antiviral activity requires an optimal number and distance of the positive charges.
dc.language.isoen
dc.publisherAMER CHEMICAL SOC
dc.relation.ispartofJOURNAL OF MEDICINAL CHEMISTRY
dc.subjectAIDS
dc.subjectASSAY
dc.subjectChemistry, Medicinal
dc.subjectEXPRESSION
dc.subjectHIV-1
dc.subjectHTLV
dc.subjectHUMAN-IMMUNODEFICIENCY-VIRUS
dc.subjectMECHANISM
dc.subjectPharmacology & Pharmacy
dc.subjectPOTENT
dc.subjectREPLICATION
dc.subjectTYPE-1
dc.title``Viologen'' Dendrimers as Antiviral Agents: The Effect of Charge Number and Distance
dc.typejournal article
dc.identifier.doi10.1021/jm100093p
dc.identifier.isiISI:000277352800005
dc.description.volume53
dc.description.issue9
dc.description.startpage3480
dc.description.endpage3488
dc.contributor.orcid0000-0002-2985-8890
dc.identifier.eissn15204804
dc.publisher.place1155 16TH ST, NW, WASHINGTON, DC 20036 USA
dcterms.isPartOf.abbreviationJ. Med. Chem.
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