DC Field | Value | Language |
dc.contributor.author | Wieczorek, Helmut | |
dc.contributor.author | Beyenbach, Klaus W. | |
dc.contributor.author | Huss, Markus | |
dc.contributor.author | Vitavska, Olga | |
dc.date.accessioned | 2021-12-23T16:08:30Z | - |
dc.date.available | 2021-12-23T16:08:30Z | - |
dc.date.issued | 2009 | |
dc.identifier.issn | 00220949 | |
dc.identifier.uri | https://osnascholar.ub.uni-osnabrueck.de/handle/unios/8319 | - |
dc.description.abstract | Active transepithelial cation transport in insects was initially discovered in Malpighian tubules, and was subsequently also found in other epithelia such as salivary glands, labial glands, midgut and sensory sensilla. Today it appears to be established that the cation pump is a two-component system of a H+-transporting V-ATPase and a cation/nH(+) antiporter. After tracing the discovery of the V-ATPase as the energizer of K+/nH(+) antiport in the larval midgut of the tobacco hornworm Manduca sexta we show that research on the tobacco hornworm V-ATPase delivered important findings that emerged to be of general significance for our knowledge of V-ATPases, which are ubiquitous and highly conserved proton pumps. We then discuss the V-ATPase in Malpighian tubules of the fruitfly Drosophila melanogaster where the potential of post-genomic biology has been impressively illustrated. Finally we review an integrated physiological approach in Malpighian tubules of the yellow fever mosquito Aedes aegypti which shows that the V-ATPase delivers the energy for both transcellular and paracellular ion transport. | |
dc.description.sponsorship | Deutsche ForschungsgemeinschaftGerman Research Foundation (DFG) [SFB 431]; VolkswagenStiftungVolkswagen; NSFNational Science Foundation (NSF) [IOB 0542797]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R21 AI072102]; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Allergy & Infectious Diseases (NIAID) [R21AI072102] Funding Source: NIH RePORTER; Supported by grants awarded to H. W. and M. H. from the Deutsche Forschungsgemeinschaft (SFB 431) and the VolkswagenStiftung (Funding Initiative `Interplay between Molecular Conformations and Biological Function') and by NSF grant IOB 0542797 and NIH grant R21 AI072102 awarded to K. W. B. Deposited in PMC for release after 12 months. | |
dc.language.iso | en | |
dc.publisher | COMPANY OF BIOLOGISTS LTD | |
dc.relation.ispartof | JOURNAL OF EXPERIMENTAL BIOLOGY | |
dc.subject | Aedes aegypti | |
dc.subject | AEDES-AEGYPTI | |
dc.subject | ANIMAL PLASMA-MEMBRANE | |
dc.subject | Biology | |
dc.subject | BLOWFLY SALIVARY-GLANDS | |
dc.subject | Drosophila melanogaster | |
dc.subject | DROSOPHILA-MELANOGASTER | |
dc.subject | ELECTRON-MICROSCOPY | |
dc.subject | H+-ATPASE | |
dc.subject | H+-translocating vacuolar-type ATPase | |
dc.subject | insect epithelia | |
dc.subject | Life Sciences & Biomedicine - Other Topics | |
dc.subject | Manduca sexta | |
dc.subject | MOSQUITO MALPIGHIAN TUBULES | |
dc.subject | PROTEIN-KINASE-A | |
dc.subject | tobacco hornworm | |
dc.subject | TOBACCO HORNWORM MIDGUT | |
dc.subject | V-ATPase | |
dc.subject | V-ATPASE SUBUNIT | |
dc.title | Vacuolar-type proton pumps in insect epithelia | |
dc.type | review | |
dc.identifier.doi | 10.1242/jeb.030007 | |
dc.identifier.isi | ISI:000266113900004 | |
dc.description.volume | 212 | |
dc.description.issue | 11 | |
dc.description.startpage | 1611 | |
dc.description.endpage | 1619 | |
dc.identifier.eissn | 14779145 | |
dc.publisher.place | BIDDER BUILDING CAMBRIDGE COMMERCIAL PARK COWLEY RD, CAMBRIDGE CB4 4DL, CAMBS, ENGLAND | |
dcterms.isPartOf.abbreviation | J. Exp. Biol. | |
dcterms.oaStatus | Green Published, Bronze | |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.dept | Universität Osnabrück | - |
crisitem.author.dept | FB 05 - Biologie/Chemie | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.deptid | fb05 | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.parentorg | Universität Osnabrück | - |
crisitem.author.netid | WiHe990 | - |
crisitem.author.netid | HuMa001 | - |
crisitem.author.netid | ViOl437 | - |