Fat & fabulous: Bifunctional lipids in the spotlight

Autor(en): Haberkant, Per
Holthuis, Joost C. M.
Stichwörter: BINDING; Biochemistry & Molecular Biology; BIOLOGICAL-MEMBRANES; Biophysics; CARDIOLIPIN; Cell Biology; CHOLESTEROL; CLICK CHEMISTRY; DIAZIRINES; Imaging; PHOSPHOLIPID-PROTEIN INTERACTIONS; PHOTO-CROSS-LINKING; Photoaffinity labeling; PROBES; Protein-lipid interaction; Proteomics; VISUALIZATION
Erscheinungsdatum: 2014
Herausgeber: ELSEVIER SCIENCE BV
Journal: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
Volumen: 1841
Ausgabe: 8, SI
Startseite: 1022
Seitenende: 1030
Zusammenfassung: 
Understanding biological processes at the mechanistic level requires a systematic charting of the physical and functional links between all cellular components. While protein-protein and protein-nucleic acid networks have been subject to many global surveys, other critical cellular components such as membrane lipids have rarely been studied in large-scale interaction screens. Here, we review the development of photoactivatable and clickable lipid analogues-so-called bifunctional lipids-as novel chemical tools that enable a global profiling of lipid-protein interactions in biological membranes. Recent studies indicate that bifunctional lipids hold great promise in systematic efforts to dissect the elaborate crosstalk between proteins and lipids in live cells and organisms. This article is part of a Special Issue entitled Tools to study lipid functions. (C) 2014 Elsevier B.V. All rights reserved.
ISSN: 13881981
DOI: 10.1016/j.bbalip.2014.01.003

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