Quantitative, label-free and site-specific monitoring of molecular recognition: a multivariate resonance Raman approach

Autor(en): Niebling, Stephan
Kuchelmeister, Hannes Y.
Schmuck, Carsten
Schluecker, Sebastian
Stichwörter: BINDING; Chemistry; Chemistry, Multidisciplinary; RECEPTORS; TETRAPEPTIDES; WATER
Erscheinungsdatum: 2011
Herausgeber: ROYAL SOC CHEMISTRY
Journal: CHEMICAL COMMUNICATIONS
Volumen: 47
Ausgabe: 1
Startseite: 568
Seitenende: 570
Zusammenfassung: 
A site-specific and quantitative approach for label-free monitoring of molecular recognition is presented. Specifically, the binding site of an artificial receptor is probed selectively by UVRR spectroscopy. The ligand binding constant can be determined by non-negative matrix factorization.
ISSN: 13597345
DOI: 10.1039/c0cc02052d

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