Lipomatoses

DC FieldValueLanguage
dc.contributor.authorAl Ghazal, Philipp
dc.contributor.authorGroenemeyer, Lisa-Lena
dc.contributor.authorSchoen, Michael P.
dc.date.accessioned2021-12-23T16:09:07Z-
dc.date.available2021-12-23T16:09:07Z-
dc.date.issued2018
dc.identifier.issn16100379
dc.identifier.urihttps://osnascholar.ub.uni-osnabrueck.de/handle/unios/8627-
dc.description.abstractLipomatoses are benign proliferations of adipose tissue, often with typical distribution patterns, which usually occur without clear causes. In contrast to circumscribed lipomas, they develop diffusely and symmetrically and are not surrounded by a fibrous pseudocapsule. The most common form is benign symmetric lipomatosis (BSL; Launois-Bensaude syndrome), of which four types are distinguished based on the distribution pattern of hyperplastic adipose tissue. The etiology and pathogenesis of the disease are still largely unknown, although some forms appear to have a hereditary basis or to be associated with increased alcohol consumption. In some cases, mitochondrial dysfunctions have been detected. Lipomatoses may be solitary, but may also be associated with other symptoms or illnesses (comorbidity). Effective drug therapies are not known, but surgical procedures can alleviate the symptoms. Lipomatosis dolorosa, which can be distinguished from BSL, occurs predominantly in middle-aged women and is characterized by proliferation of adipose tissue and severe pain in the affected areas. Various differential diagnoses and concomitant illnesses need to be considered, in particular depression. There are no evidence-based recommendations for therapy. Repetitive lidocaine infusions can achieve temporary improvement. Recurrence after surgical intervention is not uncommon, but long-term success is also possible.
dc.language.isode
dc.publisherWILEY
dc.relation.ispartofJOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT
dc.subjectAXONAL NEUROPATHY
dc.subjectBUFFALO HUMP
dc.subjectDERCUMS-DISEASE
dc.subjectDermatology
dc.subjectDISEASE ADIPOSIS DOLOROSA
dc.subjectINTRACTABLE PAIN
dc.subjectINTRAVENOUS LIDOCAINE
dc.subjectMADELUNGS-DISEASE
dc.subjectMESSENGER-RNA
dc.subjectMITOCHONDRIAL DYSFUNCTION
dc.subjectMULTIPLE SYMMETRICAL LIPOMATOSIS
dc.titleLipomatoses
dc.typejournal article
dc.identifier.doi10.1111/ddg.13460
dc.identifier.isiISI:000427476200007
dc.description.volume16
dc.description.issue3
dc.description.startpage313
dc.description.endpage328
dc.identifier.eissn16100387
dc.publisher.place111 RIVER ST, HOBOKEN 07030-5774, NJ USA
dcterms.isPartOf.abbreviationJ. Dtsch. Dermatol. Ges.
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