Atg9 proteins, not so different after all

Autor(en): Ungermann, Christian 
Reggiori, Fulvio
Stichwörter: Atg9; ATG9A; Cell Biology; COMPLEX; EARLY STEPS; ENDOMEMBRANE SYSTEM; endosomes; PRE-AUTOPHAGOSOMAL STRUCTURE; RECYCLING ENDOSOMES; SACCHAROMYCES-CEREVISIAE; SELECTIVE AUTOPHAGY; TRAFFICKING; trans-Golgi network; VACUOLE TARGETING PATHWAY; VESICLE FORMATION
Erscheinungsdatum: 2018
Herausgeber: TAYLOR & FRANCIS INC
Journal: AUTOPHAGY
Volumen: 14
Ausgabe: 8
Startseite: 1456
Seitenende: 1459
Zusammenfassung: 
Macroautophagy (hereafter autophagy) is a catabolic pathway present in all eukaryotic cells. The yeast Saccharomyces cerevisiae has been pivotal in the identification and characterization of the key autophagy-related (Atg) proteins, which play a central role in the generation of autophagosomes. The components of the core Atg/ATG machinery and their functions are highly conserved among species, although mammalian cells also have isoforms and auxiliary factors. Atg9/ATG9 is the only transmembrane protein that is part of the core Atg/ATG machinery, but it appears to have divergent localizations and molecular roles in yeast and mammals. A recent experimental analysis of the yeast endo-lysosomal system by the laboratory of Benjamin Glick, however, suggests a more simple organization of this membrane system. Although this study has not examined yeast Atg9, its findings place this protein in the same compartments as its mammalian counterpart. Here, we will discuss the implications of this conceptual change on the trafficking of yeast Atg9 and its function in autophagy.
ISSN: 15548627
DOI: 10.1080/15548627.2018.1477382

Show full item record

Page view(s)

2
Last Week
0
Last month
1
checked on Feb 26, 2024

Google ScholarTM

Check

Altmetric